Biodegradable fiducial markers for X-ray imaging - soft tissue integration and biocompatibility

Żaneta Górecka , Juliane Teichmann , Mirko Nitschke , Adrian Chlanda , Emilia Choińska , C. Werner , Wojciech Święszkowski


This study aims at the development of materials for biodegradable fiducial markers for X-ray based medical imaging and their anchorage in soft tissue. Towards this goal a degradable polymer matrix of poly(L-lactide-co-epsilon-caprolactone) (P[LAcoCL]) was combined with barium sulfate (BaSO4) and hydroxyapatite (HAp) as radio-opaque fillers. Low pressure plasma treatment was applied to the composite materials to improve cell adhesion and subsequent tissue integration. In particular, the effects of oxygen and ammonia plasmas were evaluated and compared using X-ray photoelectron spectroscopy, atomic force microscopy and dynamic water contact angle measurements as well as in vitro studies using the murine fibroblast cell line L929. To exclude the cytotoxic effects of degradation products of P[LAcoCL] and released BaSO4 or HAp cytotoxicity assays with the degradation products of the composite materials were conducted. The results obtained by this broad range of analytical techniques suggest the application of composites of P[LAcoCL] with BaSO4 and HAp as promising material systems for innovative fiducial markers for soft tissue in X-ray based medical imaging.
Author Żaneta Górecka (FMSE / DMD)
Żaneta Górecka,,
- Division of Materials Design
, Juliane Teichmann - [Leibniz-Institut für Polymerforschung Dresden e.V.]
Juliane Teichmann,,
, Mirko Nitschke - [Leibniz-Institut für Polymerforschung Dresden e.V.]
Mirko Nitschke,,
, Adrian Chlanda (FMSE / DMD)
Adrian Chlanda,,
- Division of Materials Design
, Emilia Choińska (FMSE / DMD)
Emilia Choińska,,
- Division of Materials Design
, C. Werner - [Leibniz-Institut für Polymerforschung Dresden e.V.]
C. Werner,,
, Wojciech Święszkowski (FMSE / DMD)
Wojciech Święszkowski,,
- Division of Materials Design
Journal seriesJournal of Materials Chemistry B: materials for biology and medicine, ISSN 2050-750X
Issue year2016
Publication size in sheets0.6
Languageen angielski
Score (nominal)35
Score sourcejournalList
ScoreMinisterial score = 35.0, 25-06-2020, ArticleFromJournal
Ministerial score (2013-2016) = 35.0, 25-06-2020, ArticleFromJournal
Publication indicators Scopus Citations = 12; WoS Citations = 7; GS Citations = 12.0; WoS Impact Factor: 2016 = 4.543 (2) - 2016=4.787 (5)
Citation count*12 (2020-08-31)
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* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.
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