New Insight into the Synthesis and Biological Activity of the Polymeric Materials Consisting of Folic Acid and β-Cyclodextrin

Artur Kasprzak , I. P. Grudziński , M. Bamburowicz-Klimkowska , A. Parzonko , M. Gawlak , Magdalena Popławska

Abstract

This work presents a very new look at folate targeting and is focused on synthesizing and assessing the biological activity of folic acid-targeted drug delivery materials based on β-cyclodextrin. Both folic acid and β-cyclodextrin have been covalently conjugated to branched polyethylenimine as the polymeric vector. Host–guest inclusion of folic acid into a β-cyclodextrin cavity, demonstrated by means of the spectroscopic methods (2-D NMR, IR, UV– Vis), is found to be of crucial importance for biological activity of nanotherapeutics. This paper describes the very first example of the versatile synthetic approach to create the polymeric biosystems, where folic acid activity is not limited by the inclusion phenomenon. Cytotoxicity of the obtained polymeric materials against Lewis lung carcinoma cells is determined by neutral red uptake assay. Folate receptor-binding studies reveal that the developed synthetic approach enables full exploitation of the potential of folic acid as a targeting ligand.
Publication typeOriginal work published as abstract
Author Artur Kasprzak (FC / DOC)
Artur Kasprzak,,
- Department Of Organic Chemistry
, I. P. Grudziński
I. P. Grudziński,,
-
, M. Bamburowicz-Klimkowska
M. Bamburowicz-Klimkowska,,
-
, A. Parzonko
A. Parzonko,,
-
, M. Gawlak
M. Gawlak,,
-
, Magdalena Popławska (FC / DOC)
Magdalena Popławska,,
- Department Of Organic Chemistry
Corporate authorWarsaw University of Technology (PW)
Journal seriesMacromolecular Bioscience, ISSN 1616-5187, (A 35 pkt)
Issue year2018
Vol18
No2
Pages1-7
Publication size in sheets0.5
ASJC Classification2505 Materials Chemistry; 2507 Polymers and Plastics; 2502 Biomaterials; 1502 Bioengineering; 1305 Biotechnology
DOIDOI:10.1002/mabi.201700289
Languageen angielski
File
kasprzak7.pdf 3.7 MB
Score (nominal)0
ScoreMinisterial score = 35.0, ArticleFromJournal
Ministerial score (2013-2016) = 35.0, ArticleFromJournal
Publication indicators Scopus SNIP (Source Normalised Impact per Paper): 2017 = 0.776; WoS Impact Factor: 2017 = 3.392 (2) - 2017=3.601 (5)
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