Chirality transfer in the synthesis of 2,3-dihydro-1,4-dithiine derivatives
Wojciech J. Depa , Natalia Buszta , Piotr Guńka , Janusz Zachara , Agata Bajek-Bil , Grażyna Groszek
AbstractA new method for the synthesis of chiral 2,3-dihydro-1,4-dithiine derivatives that involves a reaction of chiral cyclic aliphatic dithioacetal in the presence of Lewis acid has been developed. The title product contains a 1,4-dithiane substituent with two stereogenic centers. The presence of a stereogenic center in the α position to the cyclic dithioacetal substrate controls the stereogenicity of two centers in the newly formed molecule whose absolute configuration is defined. The mechanism based on chirality transfer process was proposed.
|Journal series||Synthetic Communications, ISSN 0039-7911, e-ISSN 1532-2432|
|Publication size in sheets||0.5|
|Score||= 40.0, 25-08-2020, ArticleFromJournal|
|Publication indicators||: 2016 = 0.392; : 2018 = 1.439 (2) - 2018=1.407 (5)|
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