Impact of morphology-influencing factors in lecithin-based hydroxyapatite precipitation

Joanna Latocha , Michał Wojasiński , Paweł Sobieszuk , Stanisław Gierlotka , Tomasz Ciach

Abstract

Lecithin-based hydroxyapatite (HAp-LE) precipitation allows synthesis of biocompatible nanosized particles. In our previous paper regarding this process, we concluded that the concentration of lecithin gives control over the size and morphology of such particles. In this paper, a special emphasis is put on the analysis of initial pH value and reaction temperature to optimize lecithin-based synthesis conditions of the uniform spherical nanoparticles. We obtained HAp-LE in the presence of lecithin with reagent's initial pH value: 8, 9, 10 and in the reaction temperature range 24–80 °C to assess the influence of selected factors on morphology in HAp-LE precipitation process. According to scanning electron microscopy and nanoparticle tracking analysis, a pH of 10 and any synthesis temperature results in the spherical HAp-LE particles with the size around 100 nm. What is more, Fourier-transform infrared spectroscopy results indicate B-type hydroxyapatite in the precipitate. According to X-ray diffraction, mostly hydroxyapatite was obtained, but it differed in samples crystallinity because of the initial pH of synthesis. The results show that to obtain homogeneous, spherical particles, a lecithin-based synthesis should be conducted at pH 10 at any synthesis temperature.

Author Joanna Latocha (FCPE / DBBE)
Joanna Latocha,,
- Department of Biotechnology and Bioprocess Engineering
, Michał Wojasiński (FCPE / DBBE)
Michał Wojasiński,,
- Department of Biotechnology and Bioprocess Engineering
, Paweł Sobieszuk (FCPE / DBBE)
Paweł Sobieszuk,,
- Department of Biotechnology and Bioprocess Engineering
, Stanisław Gierlotka - [High Pressure Research Center of the Polish Academy of Sciences]
Stanisław Gierlotka,,
-
-
, Tomasz Ciach (FCPE / DBBE)
Tomasz Ciach,,
- Department of Biotechnology and Bioprocess Engineering
Journal seriesCeramics International, ISSN 0272-8842, e-ISSN 1873-3956, (N/A 100 pkt)
Issue year2019
Vol45
No17, Part A
Pages21220-21227
Publication size in sheets0.5
Keywords in Englishhydroxyapatite, lecithin, precipitation, nanoparticles, morphology
ASJC Classification1508 Process Chemistry and Technology; 2503 Ceramics and Composites; 2504 Electronic, Optical and Magnetic Materials; 2505 Materials Chemistry; 2508 Surfaces, Coatings and Films
DOIDOI:10.1016/j.ceramint.2019.07.103
URL https://www.sciencedirect.com/science/article/pii/S0272884219319224
Languageen angielski
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Latocha J. (i in.) - Impact of morphology...pdf 5.04 MB
Score (nominal)100
Score sourcejournalList
ScoreMinisterial score = 100.0, 20-10-2019, ArticleFromJournal
Publication indicators Scopus Citations = 0; Scopus SNIP (Source Normalised Impact per Paper): 2016 = 1.304; WoS Impact Factor: 2017 = 3.057 (2) - 2017=2.882 (5)
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* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.
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