Natural polysaccharides as a potential viscosity modifier of nebulization drugs: preliminary studies on sodium hyaluronate
- Katarzyna Ewa Dobrowolska,
- Tomasz Robert Sosnowski
Sodium hyaluronate (HANa) is a well-known natural polysaccharide valued in the bioengineering field for its biocompatible, moisturizing and rheological properties. Due to these properties, it can be also considered as a viscosity modifier excipient of nebulization drugs. As a result of atomization process in an inhaler, nebulization drugs are converted to aerosol, that is delivered to the respiratory tract. The efficiency of the therapy depends on aerosol quality which determines drug deposition in the lungs. Aerosol properties may be improved either due to changes of inhaler construction or by modification of the physicochemical properties of the drug formulation. The aim of this work is to investigate the potential application of natural polysaccharides as a viscosity modifier in the medicine formulation. This study presents the preliminary data regarding the rheological characteristics of biopolymer solutions and the properties of aerosol generated in a medical jet nebulizer. Flow curves and viscosity analysis of solutions were obtained from oscillatory rheometer. The quality of the emitted mists was evaluated by measuring droplet size distribution and output rate, using laser diffraction and gravimetric method, respectively. The results shows that the presence of HANa in aqueous samples, especially at concentrations higher than 0.1%, visibly modifies their viscosity, whereas the addition of sodium chloride plays the specific role in this process. By combined measurements of rheological properties and the performance of the selected jet nebulizer (aerosolization rate, aerosol characteristics) it was possible to obtain a deeper understanding of atomization process itself and its usefulness in a better drug targeting during inhalation.
- Record ID
- Publication type
- Article number
- EYEC Monograph: 9th European Young Engineers Conference, 2021, Warszawa, Politechnika Warszawska, Wydział Inżynierii Chemicznej i Procesowej, 183 p., ISBN 978-83-936575-9-9
- Keywords in English
- viscosity modifier, atomization, potential drug excipient, aerosol properties, sodium hyaluronate
- Related project
- [UMO-2019/33/N/ST8/01181 ] Badanie właściwości substancji pochodzenia naturalnego jako potencjalnych funkcjonalnych składników leków inhalacyjnych podawanych z nebulizatorów.. . Project leader at WUT: Katarzyna Ewa Dobrowolska,
, start date 31-01-2020, end date 30-01-2022, , in run
Projects financed by NSC [Projekty finansowane przez NCN]
- eng (en) English
- Score (nominal)
- Additional fields
- Uwagi: This work was supported by National Science Centre project No. 2019/33/N/ST8/01181.
- Uniform Resource Identifier
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