Thiated pyrimidine deoxynucleoside analogues, potential chemotherapeutic agents, and substrates/inhibitors in various enzyme systems

Maria Bretner , Krzysztof Felczak , Jolanta M. Dzik , Barbara Gołos , Wojciech Rode , A. Drabikowska , J Poznański , K. Krawiec , A. Piasek , D. Shugar , Tadeusz Kulikowski

Abstract

Abstract The synthesis of thated nucleoside and nucleotide analogues, and determination of their structures, conformations, potential chemotherapeutic activities, and substratehnhibitor properties in various enzyme systems, with emphasis on enzymes related to chemotherapeutic activities, are reported.
Author Maria Bretner (FC / IBC / DDTB)
Maria Bretner,,
- Department Of Drug Technology And Biotechnology
, Krzysztof Felczak (PEC)
Krzysztof Felczak,,
- The Phisical Education Centre
, Jolanta M. Dzik - [Nencki Institute of Experimental Biology of the Polish Academy of Sciences]
Jolanta M. Dzik,,
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, Barbara Gołos - [Nencki Institute of Experimental Biology of the Polish Academy of Sciences]
Barbara Gołos,,
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, Wojciech Rode - [Nencki Institute of Experimental Biology of the Polish Academy of Sciences]
Wojciech Rode,,
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, A. Drabikowska - [Institute of Biochemistry and Biophysics of the Polish Academy of Sciences]
A. Drabikowska,,
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, J Poznański - [Institute of Biochemistry and Biophysics of the Polish Academy of Sciences]
J Poznański,,
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, K. Krawiec - [University of Warsaw (UW)]
K. Krawiec,,
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- Uniwersytet Warszawski
, A. Piasek - [SP ZOZ Wojewódzki Szpital Zakazny - Centrum Diagnostyki i Terapii AIDS, Warszawa]
A. Piasek,,
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, D. Shugar - [Institute of Biochemistry and Biophysics of the Polish Academy of Sciences]
D. Shugar,,
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et al.`
Journal seriesNucleosides Nucleotides & Nucleic Acids, [Nucleosides and Nucleotides], ISSN 1525-7770, [1532-2335]
Issue year1997
Vol16
No7-9
Pages1295-1299
ASJC Classification1311 Genetics; 1303 Biochemistry; 1313 Molecular Medicine; 2700 General Medicine
DOIDOI:10.1080/07328319708006174
URL http://dx.doi.org/10.1080/07328319708006174 <p>
Languageen angielski
Score (nominal)15
Score sourcejournalList
Publication indicators Scopus Citations = 8; WoS Citations = 8; Scopus SNIP (Source Normalised Impact per Paper): 2014 = 0.591; WoS Impact Factor: 2006 = 0.671 (2) - 2007=0.657 (5)
Citation count*8 (2015-04-24)
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* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.
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