Analytical methodology for studying cellular uptake, processing and localization of gold nanoparticles

Magdalena Matczuk , Lena Ruzik , S.S. Aleksenko , B.K. Keppler , Maciej Jarosz , A.R. Timerbaev

Abstract

Interactions of gold nanoparticles (AuNPs) with live cells are known to exert a great impact on their functions, including cell signalling, genomic, proteomic, and metabolomic processes. Modern analytical techniques applied to studying nanoparticle–cell interactions are to improve our understanding of the mode of action of AuNPs, which is essential for their approval in disease therapeutics. Such methods may vary depending on what step of particle internalization is in question, i.e., cellular uptake, intracellular transport (accompanying by changes in the chemical state), translocation to different cell compartments, interaction with relevant subcellular structures and localization. This review focuses on the implementation and critical assessment of advanced analytical methodologies to investigate the cellular processing of AuNPs. Also addressed is a sought-after issue of accounting in in-vitro studies for a chemical form in which the AuNPs enter the cell in vivo.
Author Magdalena Matczuk (FC / CAC)
Magdalena Matczuk,,
- Chair Of Analytical Chemistry
, Lena Ruzik (FC / CAC)
Lena Ruzik,,
- Chair Of Analytical Chemistry
, S.S. Aleksenko - [Saratov State Vavilov Agrarian University]
S.S. Aleksenko,,
-
-
, B.K. Keppler - [Universitat Wien]
B.K. Keppler,,
-
-
, Maciej Jarosz (FC / CAC)
Maciej Jarosz,,
- Chair Of Analytical Chemistry
, A.R. Timerbaev (FC / CAC)
A.R. Timerbaev,,
- Chair Of Analytical Chemistry
Journal seriesAnalytica Chimica Acta, ISSN 0003-2670, (N/A 100 pkt)
Issue year2019
Vol1052
Pages1-9
Publication size in sheets0.5
Keywords in English gold nanoparticles, cellular uptake, cellular processing, in vivo, in vitro
ASJC Classification1607 Spectroscopy; 2304 Environmental Chemistry; 1303 Biochemistry; 1602 Analytical Chemistry
DOIDOI:10.1016/j.aca.2018.10.027
URL https://www.ncbi.nlm.nih.gov/pubmed/30685026
Languageen angielski
File
wdpb_publikacje_pliki_plik_publikacja_3643_org.pdf 1.35 MB
Score (nominal)100
Score sourcejournalList
ScoreMinisterial score = 100.0, 03-02-2020, ArticleFromJournal
Publication indicators Scopus Citations = 2; WoS Citations = 1; Scopus SNIP (Source Normalised Impact per Paper): 2018 = 1.386; WoS Impact Factor: 2018 = 5.256 (2) - 2018=5.174 (5)
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