A computing system for the clinical and experimental investigation of cerebrovascular reactivity

Peter Smielewski , Marek Czosnyka , Wojciech Zabołotny , Peter J. Kirkpatrick , Hugh K. Richards , John D. Pickard


We present a computing system for the recording and on-line analysis of analogue signals derived from bedside cerebrovascular monitors in different pathophysiological conditions. These include arterial blood pressure and oxygen saturation, end-tidal carbon dioxide concentration, cerebral blood flow velocities using transcranial Doppler ultrasonography, and concentration changes in cerebral oxy- and deoxyhaemoglobin from near infrared spectroscopy. Configuration and analysis adopts arithmetic expressions of different signal processing functions, various statistical properties for each signal, frequency spectrum analysis using fast Fourier transformation, and correlation/cross-correlation. The software offers off-line analysis of non-invasive tests of cerebrovascular reactivity. Several examples of clinical assessment of cerebrovascular reactivity are presented, including cerebral haemodynamic stress tests which employ carbon dioxide, acetazolamide, the breath holding test, leg cuff inflation and deflation, and transient carotid artery compression. Application within the experimental setting with induced haemorrhagic hypotension can also be used.
Author Peter Smielewski
Peter Smielewski,,
, Marek Czosnyka (FEIT / PE)
Marek Czosnyka,,
- The Institute of Electronic Systems
, Wojciech Zabołotny (FEIT / PE)
Wojciech Zabołotny,,
- The Institute of Electronic Systems
, Peter J. Kirkpatrick
Peter J. Kirkpatrick,,
, Hugh K. Richards
Hugh K. Richards,,
, John D. Pickard
John D. Pickard,,
Journal seriesInternational Journal of Clinical Monitoring and Computing, ISSN 0167-9945
Issue year1997
Publication size in sheets0.65
Keywords in Englishautoregulation; cerebrovascular reactivity; computer-aided diagnosis; multimodality monitoring; waveform analysis
ASJC Classification2701 Medicine (miscellaneous); 2706 Critical Care and Intensive Care Medicine
URL https://link.springer.com/article/10.1007%2FBF03356593
Languageen angielski
Score (nominal)0
Score sourcejournalList
Publication indicators Scopus Citations = 23; WoS Citations = 23; GS Citations = 27.0; Scopus SNIP (Source Normalised Impact per Paper) [Not active]: 1999 = 0.515
Citation count*27 (2020-08-22)
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* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.
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