Mixture toxicity of pharmaceuticals present in wastewater to aquatic organisms

Katarzyna Anna Affek , Monika Załęska-Radziwiłł , Nina Doskocz , Kaja Dębek


The aim of this study is the assessment of the impact of mixture of three pharmaceutical substances (ciprofloxacin, 17α-ethinylestradiol and 5-fluorouracil) on aquatic animals, cyanobacteria and plants. Based on previous work and literature data, three concentrations of each substance were used to prepare mixtures: predicted or measured environmental concentrations (PEC/MEC), predicted no effect concentrations (PNEC), concentrations that induced a response of 10% in bioindicators (EC10). Immobilization tests with crustaceans (Daphnia magna and Artemia salina), growth tests with cyanobacteria (Cyanosarcina sp.), algae (Desmodesmus quadricauda, Raphidocelis subcapitata) and plants (Lemna minor), enzymatic test Fluotox and reproduction test with D. magna were performed. The results of this work confirm the importance of low concentration mixture exposure. Effect in PEC/MEC concentrations of the mixture of tested compounds was equal 15% in R. subcapitata growth test. As expected, effects obtained for mixtures of pharmaceuticals in their EC10 concentrations were frequently higher than 10%. The obtained results were compared with the concept of independent action, which either underestimated or overestimated the effects in concentrations used. The results obtained in this study suggest that the exposure to tested mixtures of pharmaceuticals even in low concentrations of components, that individually cause no harm to organisms, may trigger adverse effects in aquatic environment.
Author Katarzyna Anna Affek (FEE / DB)
Katarzyna Anna Affek,,
- Department of Biology
, Monika Załęska-Radziwiłł (FEE / DB)
Monika Załęska-Radziwiłł,,
- Department of Biology
, Nina Doskocz (FEE / DB)
Nina Doskocz,,
- Department of Biology
, Kaja Dębek - [Warsaw University of Technology (PW)]
Kaja Dębek,,
- Politechnika Warszawska
Journal seriesDesalination and Water Treatment, ISSN 1944-3994
Issue year2018
Publication size in sheets0.5
ConferenceMikrozanieczyszczenia w środowisku człowieka, XIII Konferencja Naukowa, 04-12-2017 - 06-12-2017, Czestochowa, Polska
Keywords in EnglishMixture ecotoxicity, Pharmaceuticals, Ciprofloxacin, 17α-Ethinylestradiol, 5-Fluorouracil
ASJC Classification2310 Pollution; 2212 Ocean Engineering; 2312 Water Science and Technology
Languageen angielski
Score (nominal)20
Score sourcejournalList
ScoreMinisterial score = 20.0, 08-07-2020, ArticleFromJournal
Publication indicators WoS Citations = 3; Scopus Citations = 3; GS Citations = 3.0; Scopus SNIP (Source Normalised Impact per Paper): 2018 = 0.509; WoS Impact Factor: 2018 = 1.234 (2) - 2018=1.29 (5)
Citation count*5 (2020-07-26)
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* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.
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