Glucose dithiocarbamate derivatives as capping ligands of water-soluble CdSeS/ZnS quantum dots

Marcin Drozd , Mariusz Pietrzak , Dominika Kalinowska , Ilona Grabowska-Jadach , Elżbieta Malinowska

Abstract

In the framework of presented study selected glucose analogues: 1-thio-β-d-glucose (βDG-SH), D-glucosamine dithiocarbamate (DG-DTC) and N-methyl-d-glucamine dithiocarbamate (NMDG-DTC) were used to modify CdSexS1-x/ZnS quantum dots via ligand exchange. The special emphasis was put on the careful optimization of DTC synthesis in an aqueous media. Properties of primary and secondary dithiocarbamates, such as stability in solutions of various pH and capability to form complexes with the divalent ions, which are crucial for their applications as surface ligands of QDs, were thoroughly compared. Due to the facility of DTCs preparation as well as colloidal stability and good optical properties of obtained hydrophilic QDs, DTC-derivatives turn out to be an alternative to most commonly used thiolated ligands. Examination of biological activity of DTC-modified QDs on A549 cell line revealed that DTC-ligands exhibit negligible intrinsic cytotoxicity. Biomimetic character of anchored ligands (similar to glucose) combined with satisfactory physicochemical properties of obtained QDs, such as high hydrophilicity and uncharged surface, indicate the potential of so modified QDs for cellular imaging and biosensing.
Author Marcin Drozd ZMB
Marcin Drozd,,
- Department Of Microbioanalytics
, Mariusz Pietrzak ZMB
Mariusz Pietrzak,,
- Department Of Microbioanalytics
, Dominika Kalinowska ZMB
Dominika Kalinowska,,
- Department Of Microbioanalytics
, Ilona Grabowska-Jadach ZMB
Ilona Grabowska-Jadach,,
- Department Of Microbioanalytics
, Elżbieta Malinowska ZMB
Elżbieta Malinowska,,
- Department Of Microbioanalytics
Journal seriesColloids and Surfaces A-Physicochemical and Engineering Aspects, ISSN 0927-7757
Issue year2016
Vol509
Pages656-665
Publication size in sheets0.5
Keywords in EnglishDithiocarbamate; Quantum dots; Cadmium selenide; Ligand exchange; Cytotoxicity
DOIDOI:10.1016/j.colsurfa.2016.09.072
URL http://www.sciencedirect.com/science/article/pii/S0927775716308226
Languageen angielski
File
1-s2.0-S0927775716308226-main.pdf (file archived - login or check accessibility on faculty) 1-s2.0-S0927775716308226-main.pdf 1.44 MB
Score (nominal)30
ScoreMinisterial score = 30.0, 28-11-2017, ArticleFromJournal
Ministerial score (2013-2016) = 30.0, 28-11-2017, ArticleFromJournal
Publication indicators WoS Impact Factor: 2016 = 2.714 (2) - 2016=2.838 (5)
Citation count*0
Cite
Share Share



* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.
Back