Glucose dithiocarbamate derivatives as capping ligands of water-soluble CdSeS/ZnS quantum dots

Marcin Drozd , Mariusz Pietrzak , Dominika Kalinowska , Ilona Grabowska-Jadach , Elżbieta Malinowska


In the framework of presented study selected glucose analogues: 1-thio-β-d-glucose (βDG-SH), D-glucosamine dithiocarbamate (DG-DTC) and N-methyl-d-glucamine dithiocarbamate (NMDG-DTC) were used to modify CdSexS1-x/ZnS quantum dots via ligand exchange. The special emphasis was put on the careful optimization of DTC synthesis in an aqueous media. Properties of primary and secondary dithiocarbamates, such as stability in solutions of various pH and capability to form complexes with the divalent ions, which are crucial for their applications as surface ligands of QDs, were thoroughly compared. Due to the facility of DTCs preparation as well as colloidal stability and good optical properties of obtained hydrophilic QDs, DTC-derivatives turn out to be an alternative to most commonly used thiolated ligands. Examination of biological activity of DTC-modified QDs on A549 cell line revealed that DTC-ligands exhibit negligible intrinsic cytotoxicity. Biomimetic character of anchored ligands (similar to glucose) combined with satisfactory physicochemical properties of obtained QDs, such as high hydrophilicity and uncharged surface, indicate the potential of so modified QDs for cellular imaging and biosensing.
Author Marcin Drozd (FC / IBC / DM)
Marcin Drozd,,
- Department Of Microbioanalytics
, Mariusz Pietrzak (FC / IBC / DM)
Mariusz Pietrzak,,
- Department Of Microbioanalytics
, Dominika Kalinowska (FC / IBC / DM)
Dominika Kalinowska,,
- Department Of Microbioanalytics
, Ilona Grabowska-Jadach (FC / IBC / DM)
Ilona Grabowska-Jadach,,
- Department Of Microbioanalytics
, Elżbieta Malinowska (FC / IBC / DM)
Elżbieta Malinowska,,
- Department Of Microbioanalytics
Journal seriesColloids and Surfaces A-Physicochemical and Engineering Aspects, ISSN 0927-7757
Issue year2016
Publication size in sheets0.5
Keywords in EnglishDithiocarbamate; Quantum dots; Cadmium selenide; Ligand exchange; Cytotoxicity
ASJC Classification1505 Colloid and Surface Chemistry
Languageen angielski
1-s2.0-S0927775716308226-main.pdf 1.44 MB
Score (nominal)30
Score sourcejournalList
ScoreMinisterial score = 30.0, 17-08-2020, ArticleFromJournal
Ministerial score (2013-2016) = 30.0, 17-08-2020, ArticleFromJournal
Publication indicators WoS Citations = 4; Scopus Citations = 4; Scopus SNIP (Source Normalised Impact per Paper): 2016 = 1.136; WoS Impact Factor: 2016 = 2.714 (2) - 2016=2.838 (5)
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