Adsorption dynamics of model pulmonary surfactants at the air/water interface: a comparison of existing mathematical models

Katarzyna Kramek-Romanowska , Tomasz Robert Sosnowski


Pulmonary surfactants (PS) are mixtures of lipids and proteins suspended as vesicles or other aggregates in the alveolar fluid. A functional PS adsorbs rapidly, probably within a few seconds or faster, at the air–water interface of the lungs. As a result the surface tension of the alveolar surface is decreased. The dependence of surface tension on surface lifetime is determined by surfactants adsorption/desorption processes at a newly created air–liquid interface. There are two approaches to describe the dynamics of adsorption at air-liquid interfaces. The diffusion controlled model assumes that the diffusional transport of interfacially active molecules through the bulk is the rate limiting process and that the adsorption is instantaneous. In the kinetic model, the adsorption and desorption steps are the rate limiting processes. In this work, existing models and their applicability to model pulmonary surfactants are discussed.
Author Katarzyna Kramek-Romanowska (FCPE / CIPE)
Katarzyna Kramek-Romanowska,,
- Chair of Integrated Process Engineering
, Tomasz Robert Sosnowski (FCPE / CIPE)
Tomasz Robert Sosnowski,,
- Chair of Integrated Process Engineering
Book The 22nd Polish Conference of Chemical and Process Engineering: Proceedings, 2016, Łódź, Faculty of Process and Environmental Engineering, ISBN 978-83-61997-75-7, 1584 p.
Proceedings OKIChiP 2016.pdf / No licence information (file archived - login or check accessibility on faculty)
Keywords in Englishpulmonary surfactant, adsorption, dynamic surface tension
Languageen angielski
Kramek et al SPALA 2016.pdf 579.09 KB
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