Dextran nanoparticle synthesis and properties
Iga Wasiak , Aleksandra Anna Kulikowska , Magdalena Janczewska , Magdalena Michalak , Iwona A. Cymerman , Andrzej Nagalski , Peter Kallinger , Władysław W. Szymański , Tomasz Ciach
AbstractDextran is widely exploited in medical products and as a component of drug-delivering nanoparticles (NPs). Here, we tested whether dextran can serve as the main substrate of NPs and form a stable backbone. We tested dextrans with several molecular masses under several synthesis conditions to optimize NP stability. The analysis of the obtained nanoparticles showed that dextran NPs that were synthesized from 70 kDa dextran with a 5% degree of oxidation of the polysaccharide chain and 50% substitution with dodecylamine formed a NP backbone composed of modified dextran subunits, the mean diameter of which in an aqueous environment was around 100 nm. Dextran NPs could be stored in a dry state and reassembled in water. Moreover, we found that different chemical moieties (e.g., drugs such as doxorubicin) can be attached to the dextran NPs via a pH-dependent bond that allows release of the drug with lowering pH. We conclude that dextran NPs are a promising nano drug carrier.
|Journal series||Plos One, ISSN 1932-6203|
|Publication size in sheets||0.8|
|Score|| = 35.0, 28-11-2017, ArticleFromJournal|
= 40.0, 28-11-2017, ArticleFromJournal
|Publication indicators||: 2016 = 2.806 (2) - 2016=3.394 (5)|
|Citation count*||12 (2018-02-21)|
* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.