Dextran nanoparticle synthesis and properties

Iga Wasiak , Aleksandra Anna Kulikowska , Magdalena Janczewska , Magdalena Michalak , Iwona A. Cymerman , Andrzej Nagalski , Peter Kallinger , Władysław W. Szymański , Tomasz Ciach

Abstract

Dextran is widely exploited in medical products and as a component of drug-delivering nanoparticles (NPs). Here, we tested whether dextran can serve as the main substrate of NPs and form a stable backbone. We tested dextrans with several molecular masses under several synthesis conditions to optimize NP stability. The analysis of the obtained nanoparticles showed that dextran NPs that were synthesized from 70 kDa dextran with a 5% degree of oxidation of the polysaccharide chain and 50% substitution with dodecylamine formed a NP backbone composed of modified dextran subunits, the mean diameter of which in an aqueous environment was around 100 nm. Dextran NPs could be stored in a dry state and reassembled in water. Moreover, we found that different chemical moieties (e.g., drugs such as doxorubicin) can be attached to the dextran NPs via a pH-dependent bond that allows release of the drug with lowering pH. We conclude that dextran NPs are a promising nano drug carrier.
Author Iga Wasiak (FCPE / DBBE)
Iga Wasiak,,
- Department of Biotechnology and Bioprocess Engineering
, Aleksandra Anna Kulikowska (FCPE / DBBE)
Aleksandra Anna Kulikowska,,
- Department of Biotechnology and Bioprocess Engineering
, Magdalena Janczewska (FCPE / DBBE)
Magdalena Janczewska,,
- Department of Biotechnology and Bioprocess Engineering
, Magdalena Michalak (FCPE)
Magdalena Michalak,,
- Faculty of Chemical and Process Engineering
, Iwona A. Cymerman - [NanoVelos Sp. z o.o.]
Iwona A. Cymerman,,
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, Andrzej Nagalski - [NanoVelos Sp. z o.o.]
Andrzej Nagalski,,
-
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, Peter Kallinger - [Universitat Wien]
Peter Kallinger,,
-
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, Władysław W. Szymański - [Universitat Wien]
Władysław W. Szymański,,
-
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, Tomasz Ciach (FCPE / DBBE)
Tomasz Ciach,,
- Department of Biotechnology and Bioprocess Engineering
Journal seriesPlos One, ISSN 1932-6203
Issue year2016
Vol11
No1
Pages1-17
Publication size in sheets0.8
ASJC Classification1100 General Agricultural and Biological Sciences; 1300 General Biochemistry, Genetics and Molecular Biology; 2700 General Medicine
DOIDOI:10.1371/journal.pone.0146237
URL http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0146237
Languageen angielski
File
Wasiak I. (i in.) - Dextran nanoparticle synthesis....PDF 2.19 MB
Score (nominal)40
Score sourcejournalList
ScoreMinisterial score = 35.0, 18-08-2020, ArticleFromJournal
Ministerial score (2013-2016) = 40.0, 18-08-2020, ArticleFromJournal
Publication indicators Scopus Citations = 20; WoS Citations = 23; GS Citations = 34.0; Scopus SNIP (Source Normalised Impact per Paper): 2016 = 1.101; WoS Impact Factor: 2016 = 2.806 (2) - 2016=3.394 (5)
Citation count*37 (2020-08-27)
Additional fields
Numer artykułue0146237
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* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.
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