Electrochemical studies of binary and ternary copper(II) complexes with α-factor analogues

Iwona Ufnalska , Urszula Wawrzyniak , K. Bossak-Ahmad , Wojciech Bal , Wojciech Wróblewski


Copper(II) binding properties of Saccharomyces cerevisiae pheromone (α-factor) analogues, namely WHWSKNR-am, FHWSKNR-am and WHFSKNR-am amino acid sequences, were studied using voltammetry techniques, fluorescence and UV–Vis spectroscopy. Despite the same 3N binding mode attributed to XHZ-type oligopeptides, the obtained results demonstrated high dependence of the electrochemical properties of their copper(II) complexes on the metal ion coordination environment. Changes triggered by ternary complex formation with imidazole molecule, leading to 4N structure formation, were also examined. The investigated derivatives underwent reduction and oxidation processes as well, however the coordination sphere affected mainly the anodic signal. Different electrochemical responses of α-factor analogues revealed significant influence of tryptophan residue position in a peptide sequence and indicated the complexity of ongoing redox processes. That stems from the presence of two different redox active centers and the possibility of the occurrence of multiple electrostatic interactions engaging charged groups, metal cation and indole moiety.

Author Iwona Ufnalska (FC / CMB)
Iwona Ufnalska,,
- Chair of Medical Biotechnology
, Urszula Wawrzyniak (FC / CMB)
Urszula Wawrzyniak,,
- Chair of Medical Biotechnology
, K. Bossak-Ahmad - [Institute of Biochemistry and Biophysics of the Polish Academy of Sciences]
K. Bossak-Ahmad,,
, Wojciech Bal - [Institute of Biochemistry and Biophysics of the Polish Academy of Sciences]
Wojciech Bal,,
, Wojciech Wróblewski (FC / CMB)
Wojciech Wróblewski,,
- Chair of Medical Biotechnology
Journal seriesJournal of Electroanalytical Chemistry, ISSN 1572-6657, e-ISSN 1873-2569
Issue year2020
Publication size in sheets0.3
ASJC Classification1500 General Chemical Engineering; 1602 Analytical Chemistry; 1603 Electrochemistry
URL https://www.sciencedirect.com/science/article/pii/S1572665720301867
Languageen angielski
wdpb_publikacje_pliki_plik_publikacja_3953_org.pdf 1.14 MB
Score (nominal)70
Score sourcejournalList
ScoreMinisterial score = 70.0, 07-08-2020, ArticleFromJournal
Publication indicators Scopus Citations = 0; Scopus SNIP (Source Normalised Impact per Paper): 2018 = 0.813; WoS Impact Factor: 2018 = 3.218 (2) - 2018=3.032 (5)
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