Co-axial wet-spinning in 3D bioprinting: state of the art and future perspective of microfluidic integration

Marco Costantini , C. Colosi , Wojciech Święszkowski , Andrea Barbetta

Abstract

Nowadays, 3D bioprinting technologies are rapidly emerging in the field of tissue engineering and regenerative medicine as effective tools enabling the fabrication of advanced tissue constructs that can recapitulate in vitro organ/tissue functions. Selecting the best strategy for bioink deposition is often challenging and time consuming process, as bioink properties—in the first instance, rheological and gelation—strongly influence the suitable paradigms for its deposition. In this short review, we critically discuss one of the available approaches used for bioprinting—namely co-axial wet-spinning extrusion. Such a deposition system, in fact, demonstrated to be promising in terms of printing resolution, shape fidelity and versatility when compared to other methods. An overview of the performances of co-axial technology in the deposition of cellularized hydrogel fibres is discussed, highlighting its main features. Furthermore, we show how this approach allows(i)to decouple the printing accuracy from bioink rheological behaviour—thus notably simplifying the development of new bioinks—and (ii)to build heterogeneous multi-materials and/or multicellular constructs that can better mimic the native tissues when combined with microfluidic systems. Finally, the ongoing challenges and the future perspectives for the ultimate fabrication of functional constructs for advanced research studies are highlighted.
Author Marco Costantini - Università Campus Bio-Medico di Roma, Rome, Italy [Universita degli Studi di Roma La Sapienza]
Marco Costantini,,
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, C. Colosi - [Centre for Life Nanoscience]
C. Colosi,,
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, Wojciech Święszkowski (FMSE / DMD)
Wojciech Święszkowski,,
- Division of Materials Design
, Andrea Barbetta - Sapienza University of Rome [Universita degli Studi di Roma La Sapienza]
Andrea Barbetta,,
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Journal seriesBiofabrication, ISSN 1758-5082, (A 45 pkt)
Issue year2018
Vol11
Pages012001-012034
Publication size in sheets1.65
Keywords in Englishalginate, bioink, 3D bioprinting, co-axial extrusion, tissue engineering, hollowfibres, microfluidics
ASJC Classification2204 Biomedical Engineering; 2700 General Medicine; 2502 Biomaterials; 1303 Biochemistry; 1502 Bioengineering; 1305 Biotechnology
DOIDOI:10.1088/1758-5090/aae605
URL https://iopscience.iop.org/article/10.1088/1758-5090/aae605/meta
Languageen angielski
Score (nominal)45
ScoreMinisterial score = 45.0, 06-02-2019, ArticleFromJournal
Ministerial score (2013-2016) = 45.0, 06-02-2019, ArticleFromJournal
Publication indicators Scopus SNIP (Source Normalised Impact per Paper): 2016 = 1.167; WoS Impact Factor: 2017 = 6.838 (2) - 2017=6.896 (5); Scopus Citations = 0; WoS Citations = 0
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