Heart-on-a-chip based on stem cell biology

Elżbieta Jastrzębska , Ewelina Tomecka , Iwona Jesion


Heart diseases are one of the main causes of death around the world. The great challenge for scientists is to develop new therapeutic methods for these types of ailments. Stem cells (SCs) therapy could be one of a promising technique used for renewal of cardiac cells and treatment of heart diseases. Conventional in vitro techniques utilized for investigation of heart regeneration do not mimic natural cardiac physiology. Lab-on-a-chip systems may be the solution which could allow the creation of a heart muscle model, enabling the growth of cardiac cells in conditions similar to in vivo conditions. Microsystems can be also used for differentiation of stem cells into heart cells, successfully. It will help better understand of proliferation and regeneration ability of these cells. In this review, we present Heart-on-a-chip systems based on cardiac cell culture and stem cell biology. This review begins with the description of the physiological environment and the functions of the heart. Next, we shortly described conventional techniques of stem cells differentiation into the cardiac cells. This review is mostly focused on describing Lab-on-a-chip systems for cardiac tissue engineering. Therefore, in the next part of this article, the microsystems for both cardiac cell culture and SCs differentiation into cardiac cells are described. The section about SCs differentiation into the heart cells is divided in sections describing biochemical, physical and mechanical stimulations. Finally, we outline present challenges and future research concerning Heart-on-a-chip based on stem cell biology.
Author Elżbieta Jastrzębska (FC / IBC / DM)
Elżbieta Jastrzębska,,
- Department Of Microbioanalytics
, Ewelina Tomecka (FC / IBC / DM)
Ewelina Tomecka,,
- Department Of Microbioanalytics
, Iwona Jesion - [Szkola Glowna Gospodarstwa Wiejskiego]
Iwona Jesion,,
Journal seriesBiosensors & Bioelectronics, ISSN 0956-5663
Issue year2016
Publication size in sheets0.7
Keywords in EnglishHeart-on-a-chip; Cardiac cells; Stem cells; Differentiation; Lab-on-a-chip
ASJC Classification1603 Electrochemistry; 2204 Biomedical Engineering; 2700 General Medicine; 1304 Biophysics; 1305 Biotechnology
URL http://www.sciencedirect.com/science/article/pii/S0956566315303390
Languageen angielski
1-s2.0-S0956566315303390-main.pdf 7.01 MB
Score (nominal)40
Score sourcejournalList
ScoreMinisterial score = 40.0, 31-01-2020, ArticleFromJournal
Ministerial score (2013-2016) = 40.0, 31-01-2020, ArticleFromJournal
Publication indicators Scopus Citations = 33; WoS Citations = 18; Scopus SNIP (Source Normalised Impact per Paper): 2016 = 1.631; WoS Impact Factor: 2016 = 7.78 (2) - 2016=6.862 (5)
Citation count*43 (2020-09-02)
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* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.
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