MicroCT Visible Hydrogels for Bone Tissue Engineering
Nehar Celikkin , Karol Szlązak , Jakub Jaroszewicz , Wojciech Święszkowski
AbstractWhen employing imaging modalities to evaluate in vivo response to implanted biomaterials, it is crucial to make quantifiable diagnostic conclusions about the biomaterial-host interactions and degree of tissue repair. micro CT is a commonly used imaging technique which provides high resolution and non-invasive visualization for hard tissue, especially on the microarchitecture, volume, surface area, tissue thickness and spatial distribution. In our study, we aim to create micro CT visible hydrogels for longitudinal tracking of scaffold degradation and tissue formation. For this purpose, we decided to create micro CT visible hydrogels by combining our hydrogel constructs with gold nanoparticles (GNPs). The alterations in mechanical properties of the hydrogels will be evaluated via dynamic mechanical analysis (DMA). Cytocompatibility and bone tissue engineering potential of the hydrogel-GNP constructs will be analysed using rat derived mesenchymal stromal cells (MSCs). Different size and concentration of GNPs will be combined with hydrogels to optimize the micro CT visibility, cytocompatibility and bone tissue engineering potential of GNP-hydrogel constructs in wet and dry state.
|Journal series||Tissue Engineering, ISSN 2152-4947, e-ISSN 2152-4955, [1076-3279]|
|Publication size in sheets||0.3|
|Conference||Termis America (TERMIS), 11-12-2016 - 14-12-2016, San Diego, California, Stany Zjednoczone|
|Publication indicators||= 0; : 2016 = 3.485 (2) - 2016=4.019 (5)|
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