MicroCT Visible Hydrogels for Bone Tissue Engineering

Nehar Celikkin , Karol Szlązak , Jakub Jaroszewicz , Wojciech Święszkowski

Abstract

When employing imaging modalities to evaluate in vivo response to implanted biomaterials, it is crucial to make quantifiable diagnostic conclusions about the biomaterial-host interactions and degree of tissue repair. micro CT is a commonly used imaging technique which provides high resolution and non-invasive visualization for hard tissue, especially on the microarchitecture, volume, surface area, tissue thickness and spatial distribution. In our study, we aim to create micro CT visible hydrogels for longitudinal tracking of scaffold degradation and tissue formation. For this purpose, we decided to create micro CT visible hydrogels by combining our hydrogel constructs with gold nanoparticles (GNPs). The alterations in mechanical properties of the hydrogels will be evaluated via dynamic mechanical analysis (DMA). Cytocompatibility and bone tissue engineering potential of the hydrogel-GNP constructs will be analysed using rat derived mesenchymal stromal cells (MSCs). Different size and concentration of GNPs will be combined with hydrogels to optimize the micro CT visibility, cytocompatibility and bone tissue engineering potential of GNP-hydrogel constructs in wet and dry state.
Publication typeOriginal work published as abstract
Author Nehar Celikkin ZPM
Nehar Celikkin,,
- Division of Materials Design
, Karol Szlązak ZPM
Karol Szlązak,,
- Division of Materials Design
, Jakub Jaroszewicz WIM
Jakub Jaroszewicz,,
- Faculty of Materials Science and Engineering
, Wojciech Święszkowski ZPM
Wojciech Święszkowski,,
- Division of Materials Design
Journal seriesTissue Engineering, ISSN 2152-4947, e-ISSN 2152-4955 [1076-3279]
Issue year2016
Vol22
NoS-1
Pages74-75
Publication size in sheets0.3
ConferenceTermis America (TERMIS), 11-12-2016 - 14-12-2016, San Diego, California, Stany Zjednoczone
Languageen angielski
File
2016 TERMIS - Americas Conference and Exhibition San Diego, CA December 11–14, 2016.pdf (file archived - login or check accessibility on faculty) 2016 TERMIS - Americas Conference and Exhibition San Diego, CA December 11–14, 2016.pdf 46.71 KB
Score (nominal)0
ScoreMinisterial score = 35.0, 28-11-2017, ArticleFromJournal
Ministerial score (2013-2016) = 35.0, 28-11-2017, ArticleFromJournal
Publication indicators WoS Impact Factor: 2016 = 3.485 (2) - 2016=4.019 (5)
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* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.
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