Polyurethane modification with acrylic acid by Ce(IV)-initiated graft polymerization

Beata Aleksandra Butruk-Raszeja , Paulina Anna Trzaskowska , Aleksandra Kuźmińska , Tomasz Ciach

Abstract

This paper presents a method for polyurethane surface functionalization for tissue engineering applications. Functionalization has been carried out by grafting acrylic acid to the polyurethane surface with the use of radical polymerization with a Ce4+ initiator. Contrary to other papers suggesting that the presence of hydroxyl groups are essential for successful grafting via ceric ions, we propose a method with the omission of the surface hydroxylation step. The influence of reaction conditions: reaction time, reaction temperature and monomer concentration on carboxyl groups surface density has been analyzed and described. The quantity of carboxyl groups on the surface was determined with the use of the TBO method. Materials grafted with acrylic acid have been subjected to conjugation with a peptide using sulfoNHS/ EDC chemistry. Successful incorporation of the peptide has been confirmed by an ELISA assay. Additionally, for better characterization, after each step of modification materials were subjected to SEM, FTIR-ATR, XPS and contact angle measurement analysis.
Author Beata Aleksandra Butruk-Raszeja ZBIB
Beata Aleksandra Butruk-Raszeja,,
- Department of Biotechnology and Bioprocess Engineering
, Paulina Anna Trzaskowska ZBIB
Paulina Anna Trzaskowska,,
- Department of Biotechnology and Bioprocess Engineering
, Aleksandra Kuźmińska ZBIB
Aleksandra Kuźmińska,,
- Department of Biotechnology and Bioprocess Engineering
, Tomasz Ciach ZBIB
Tomasz Ciach,,
- Department of Biotechnology and Bioprocess Engineering
Journal seriesOpen Chemistry, ISSN , e-ISSN 2391-5420
Issue year2016
Vol14
No1
Pages206-214
Publication size in sheets0.5
Keywords in Englishpolyurethane, surface modification, acrylic acid, peptide coating, cerium-induced grafting
DOIDOI:10.1515/chem-2016-0020
URL https://www.degruyter.com/downloadpdf/j/chem.2016.14.issue-1/chem-2016-0020/chem-2016-0020.xml
Languageen angielski
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Butruk-Raszeja B. A. (i in.) - Polyurethane modification with....pdf 2.85 MB
Score (nominal)14
ScoreMinisterial score = 14.0, 28-11-2017, ArticleFromJournal
Ministerial score (2013-2016) = 14.0, 28-11-2017, ArticleFromJournal
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