Novel Sulfones with Antifungal Properties: Antifungal Activities and Interactions with Candida spp. Virulence Factors

Małgorzata Gizińska , Monika Staniszewska , Zbigniew Ochal

Abstract

Since candidiasis is so difficult to eradicate with an antifungal treatment and the existing antimycotics display many limitations, hopefully new sulfone derivatives may overcome these deficiencies. It is pertinent to study new strategies such as sulfone derivatives targeting the virulence attributes of C. albicans that differentiate them from the host. During infections, the pathogenic potential of C. albicans relies on the virulence factors as follows: hydrolytic enzymes, transcriptional factors, adhesion, and development of biofilms. In the article we explored how the above-presented C. albicans fitness and virulence attributes provided a robust response to the environmental stress exerted by sulfones upon C. albicans; C. albicans fitness and virulence attributes are fungal properties whose inactivation attenuates virulence. Our understanding of how these mechanisms and factors are inhibited by sulfones has increased over the last years. As lack of toxicity is a prerequisite for medical approaches, sulfones (non-toxic as assessed in vitro and in vivo) may prove to be useful for reducing C. albicans pathogenesis in humans. The antifungal activity of sulfones dealing with these multiple virulence factors and fitness attributes is discussed.
Author Małgorzata Gizińska
Małgorzata Gizińska,,
-
, Monika Staniszewska
Monika Staniszewska,,
-
, Zbigniew Ochal (FC / IBC / DDTB)
Zbigniew Ochal,,
- Department Of Drug Technology And Biotechnology
Journal seriesMini-Reviews in Medicinal Chemistry, ISSN 1389-5575, (A 30 pkt)
Issue year2019
Vol19
No1
Pages12-21
Publication size in sheets0.5
Keywords in EnglishAntifungal activity, anti-virulence agents, Candida spp., fungal infections, sulfone derivatives, virulence
ASJC Classification3002 Drug Discovery; 3004 Pharmacology; 2700 General Medicine
DOIDOI:10.2174/1389557518666180924121209
URL https://www.ncbi.nlm.nih.gov/pubmed/30246638
Languageen angielski
File
wdpb_publikacje_pliki_plik_publikacja_3551_org.pdf 1.23 MB
Score (nominal)30
ScoreMinisterial score = 30.0, 14-01-2019, ArticleFromJournal
Ministerial score (2013-2016) = 30.0, 14-01-2019, ArticleFromJournal
Publication indicators Scopus SNIP (Source Normalised Impact per Paper): 2016 = 1.012; WoS Impact Factor: 2017 = 2.645 (2) - 2017=2.834 (5)
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