Binary bioactive glass composite scaffolds for bone tissue engineering—Structure and mechanical properties in micro and nano scale. A preliminary study

Michał J. Woźniak , Adrian Chlanda , Przemysław Oberbek , Marcin Heljak , Katarzyna Czarnecka , Mateusz Janeta , Łukasz John


Composite scaffolds of bioactive glass (SiO2-CaO) and bioresorbable polyesters: poly-L-lactic acid (PLLA) and polycaprolactone (PCL) were produced by polymer coating of porous foams. Their structure and mechanical properties were investigated in micro and nanoscale, by the means of scanning electron microscopy, PeakForce Quantitative Nanomechanical Property Mapping (PF-QNM) atomic force microscopy, micro-computed tomography and contact angle measurements. This is one of the first studies in which the nanomechanical properties (elastic modulus, adhesion) were measured and mapped simultaneously with topography imaging (PF-QNM AFM) for bioactive glass and bioactive glass – polymer coated scaffolds. Our findings show that polymer coated scaffolds had higher average roughness and lower stiffness in comparison to pure bioactive glass scaffolds. Such coating-dependent scaffold properties may promote different cells-scaffold interaction.
Author Michał J. Woźniak - [Warsaw University of Technology (PW)]
Michał J. Woźniak,,
- Politechnika Warszawska
, Adrian Chlanda (FMSE / DMD)
Adrian Chlanda,,
- Division of Materials Design
, Przemysław Oberbek (FMSE / DMD)
Przemysław Oberbek,,
- Division of Materials Design
, Marcin Heljak (FMSE / DMD)
Marcin Heljak,,
- Division of Materials Design
, Katarzyna Czarnecka
Katarzyna Czarnecka,,
, Mateusz Janeta - [University of Wroclaw]
Mateusz Janeta,,
, Łukasz John - [University of Wroclaw]
Łukasz John,,
Journal seriesMicron, ISSN 0968-4328
Issue year2019
Publication size in sheets0.5
Keywords in PolishInżynieria tkankowa kości, rusztowanie kompozytowe, szkło bioaktywne, właściwości mechaniczne
Keywords in EnglishBone Tissue Engineering, Composite Scaffold, Bioactive Glass, Mechanical Properties
ASJC Classification1307 Cell Biology; 1315 Structural Biology
Languageen angielski
micron_mjw.pdf 2.15 MB
Score (nominal)100
Score sourcejournalList
ScoreMinisterial score = 100.0, 06-12-2019, ArticleFromJournal
Publication indicators Scopus Citations = 2; Scopus SNIP (Source Normalised Impact per Paper): 2016 = 1.005; WoS Impact Factor: 2018 = 1.53 (2) - 2018=1.809 (5)
Citation count*5 (2020-06-19)
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* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.
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