Influence of Experimental Conditions on Electronic Tongue Results - Case of Valsartan Minitablets Dissolution
Małgorzata Wesoły , Anna Kluk , Małgorzata Sznitowska , Patrycja Ciosek , Wojciech Wróblewski
AbstractA potentiometric electronic tongue was applied to study the release of valsartan from pharmaceutical formulations, i.e., minitablets uncoated and coated with Eudragit E. Special attention was paid to evaluate the influence of medium temperature and composition, as well as to compare the performances of the sensor arrays working in various hydrodynamic conditions. The drug dissolution profiles registered with the ion-sensitive electrodes were compared with standard dissolution tests performed with USP Apparatus 2 (paddle). Moreover, the signal changes of all sensors were processed by principal component analysis to visualize the release modifications, related to the presence of the coating agent. Finally, the importance and influence of the experimental conditions on the results obtained using potentiometric sensor arrays were discussed.
|Journal series||Sensors, ISSN 1424-8220|
|Publication size in sheets||0.65|
|Keywords in English||electronic tongue, potentiometric sensors, drug release, dissolution test, minitablets, valsartan, taste-masking|
|Score|| = 30.0, 28-11-2017, ArticleFromJournal|
= 30.0, 28-11-2017, ArticleFromJournal
|Publication indicators||: 2016 = 2.677 (2) - 2016=2.964 (5)|
* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.