Influence of Experimental Conditions on Electronic Tongue Results - Case of Valsartan Minitablets Dissolution

Małgorzata Wesoły , Anna Kluk , Małgorzata Sznitowska , Patrycja Ciosek , Wojciech Wróblewski


A potentiometric electronic tongue was applied to study the release of valsartan from pharmaceutical formulations, i.e., minitablets uncoated and coated with Eudragit E. Special attention was paid to evaluate the influence of medium temperature and composition, as well as to compare the performances of the sensor arrays working in various hydrodynamic conditions. The drug dissolution profiles registered with the ion-sensitive electrodes were compared with standard dissolution tests performed with USP Apparatus 2 (paddle). Moreover, the signal changes of all sensors were processed by principal component analysis to visualize the release modifications, related to the presence of the coating agent. Finally, the importance and influence of the experimental conditions on the results obtained using potentiometric sensor arrays were discussed.
Author Małgorzata Wesoły (FC / IBC / DM)
Małgorzata Wesoły,,
- Department Of Microbioanalytics
, Anna Kluk - [Gdanski Uniwersytet Medyczny]
Anna Kluk,,
, Małgorzata Sznitowska - [Gdanski Uniwersytet Medyczny]
Małgorzata Sznitowska,,
, Patrycja Ciosek (FC / IBC / DM)
Patrycja Ciosek,,
- Department Of Microbioanalytics
, Wojciech Wróblewski (FC / IBC / DM)
Wojciech Wróblewski,,
- Department Of Microbioanalytics
Journal seriesSensors, [SENSORS-BASEL], ISSN 1424-8220
Issue year2016
Publication size in sheets0.65
Keywords in Englishelectronic tongue, potentiometric sensors, drug release, dissolution test, minitablets, valsartan, taste-masking
ASJC Classification2208 Electrical and Electronic Engineering; 1303 Biochemistry; 3107 Atomic and Molecular Physics, and Optics; 1602 Analytical Chemistry
Languageen angielski
Influence of experimental conditions on electronic tongue results - case of valsartan minitablets dissolution.pdf 1.25 MB
Score (nominal)30
Score sourcejournalList
ScoreMinisterial score = 30.0, 01-02-2020, ArticleFromJournal
Ministerial score (2013-2016) = 30.0, 01-02-2020, ArticleFromJournal
Publication indicators WoS Citations = 4; Scopus Citations = 8; Scopus SNIP (Source Normalised Impact per Paper): 2016 = 1.393; WoS Impact Factor: 2016 = 2.677 (2) - 2016=2.964 (5)
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