Influence of Experimental Conditions on Electronic Tongue Results - Case of Valsartan Minitablets Dissolution

Małgorzata Wesoły , Anna Kluk , Małgorzata Sznitowska , Patrycja Ciosek , Wojciech Wróblewski

Abstract

A potentiometric electronic tongue was applied to study the release of valsartan from pharmaceutical formulations, i.e., minitablets uncoated and coated with Eudragit E. Special attention was paid to evaluate the influence of medium temperature and composition, as well as to compare the performances of the sensor arrays working in various hydrodynamic conditions. The drug dissolution profiles registered with the ion-sensitive electrodes were compared with standard dissolution tests performed with USP Apparatus 2 (paddle). Moreover, the signal changes of all sensors were processed by principal component analysis to visualize the release modifications, related to the presence of the coating agent. Finally, the importance and influence of the experimental conditions on the results obtained using potentiometric sensor arrays were discussed.
Author Małgorzata Wesoły ZMB
Małgorzata Wesoły,,
- Department Of Microbioanalytics
, Anna Kluk
Anna Kluk,,
-
, Małgorzata Sznitowska
Małgorzata Sznitowska,,
-
, Patrycja Ciosek ZMB
Patrycja Ciosek,,
- Department Of Microbioanalytics
, Wojciech Wróblewski ZMB
Wojciech Wróblewski,,
- Department Of Microbioanalytics
Journal seriesSensors, ISSN 1424-8220
Issue year2016
Vol16
No9
Pages1353-1366
Publication size in sheets0.65
Keywords in Englishelectronic tongue, potentiometric sensors, drug release, dissolution test, minitablets, valsartan, taste-masking
DOIDOI:10.3390/s16091353
URL https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5038631/
Languageen angielski
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Influence of experimental conditions on electronic tongue results - case of valsartan minitablets dissolution.pdf 1.25 MB
Score (nominal)30
ScoreMinisterial score [Punktacja MNiSW] = 30.0, 28-11-2017, ArticleFromJournal
Ministerial score (2013-2016) [Punktacja MNiSW (2013-2016)] = 30.0, 28-11-2017, ArticleFromJournal
Publication indicators WoS Impact Factor [Impact Factor WoS]: 2016 = 2.677 (2) - 2016=2.964 (5)
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