Direct Synthesis of Polylactide (PLA)-Chlorphenesin Prodrug and Optimization Thereof with the Aid of DOE
Agnieszka Sebai , Paweł Ruśkowski , Vanessa Bijak , Agnieszka Gadomska-Gajadhur , Aleksandra Kruk , Ludwik Synoradzki
AbstractDirect, one-pot, solvent-free preparation method of macromolecular prodrug of chlorphenesin (CF, 1) and polylactide (2) was developed. It involves addition of chlorphenesin to L-lactide followed by ring-opening polymerization of the latter. The process was optimized by factorial design to maximize the conversion and simultaneously to obtain appropriately high average molecular mass of the prodrug. On the basis of a mathematical model, it is possible to control the length of polymeric chain and, thus to control duration of the therapeutic effect in case of using the prodrug as DDS.
|Journal series||Organic Process Research & Development, ISSN 1083-6160|
|Publication size in sheets||0.5|
|Keywords in English||chlorphenesin, DDS, polylactide, macromolecular prodrug, DOE|
|Abstract in Polish||xxx|
|Score|| = 35.0, 23-01-2018, ArticleFromJournal|
= 35.0, 23-01-2018, ArticleFromJournal
|Publication indicators||: 2016 = 2.857 (2) - 2016=2.801 (5)|
* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.