Direct Synthesis of Polylactide (PLA)-Chlorphenesin Prodrug and Optimization Thereof with the Aid of DOE

Agnieszka Sebai , Paweł Ruśkowski , Vanessa Bijak , Agnieszka Gadomska-Gajadhur , Aleksandra Kruk , Ludwik Synoradzki

Abstract

Direct, one-pot, solvent-free preparation method of macromolecular prodrug of chlorphenesin (CF, 1) and polylactide (2) was developed. It involves addition of chlorphenesin to L-lactide followed by ring-opening polymerization of the latter. The process was optimized by factorial design to maximize the conversion and simultaneously to obtain appropriately high average molecular mass of the prodrug. On the basis of a mathematical model, it is possible to control the length of polymeric chain and, thus to control duration of the therapeutic effect in case of using the prodrug as DDS.
Author Agnieszka Sebai LPT
Agnieszka Sebai,,
- Laboratory Of Technological Processes
, Paweł Ruśkowski LPT
Paweł Ruśkowski,,
- Laboratory Of Technological Processes
, Vanessa Bijak
Vanessa Bijak,,
-
, Agnieszka Gadomska-Gajadhur LPT
Agnieszka Gadomska-Gajadhur,,
- Laboratory Of Technological Processes
, Aleksandra Kruk LPT
Aleksandra Kruk,,
- Laboratory Of Technological Processes
, Ludwik Synoradzki LPT
Ludwik Synoradzki,,
- Laboratory Of Technological Processes
Journal seriesOrganic Process Research & Development, ISSN 1083-6160
Issue year2018
Vol22
Pages21-26
Publication size in sheets0.5
Keywords in Englishchlorphenesin, DDS, polylactide, macromolecular prodrug, DOE
Abstract in Polishxxx
DOIDOI:10.1021/acs.oprd.7b00266
Languageen angielski
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wdpb_publikacje_pliki_plik_publikacja_3381_org.pdf (file archived - login or check accessibility on faculty) wdpb_publikacje_pliki_plik_publikacja_3381_org.pdf 1.52 MB
Score (nominal)35
ScoreMinisterial score = 35.0, 23-01-2018, ArticleFromJournal
Ministerial score (2013-2016) = 35.0, 23-01-2018, ArticleFromJournal
Publication indicators WoS Impact Factor: 2016 = 2.857 (2) - 2016=2.801 (5)
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* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.
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