Direct Synthesis of Polylactide (PLA)-Chlorphenesin Prodrug and Optimization Thereof with the Aid of DOE

Agnieszka Sebai , Paweł Ruśkowski , Vanessa Bijak , Agnieszka Gadomska-Gajadhur , Aleksandra Kruk , Ludwik Synoradzki


Direct, one-pot, solvent-free preparation method of macromolecular prodrug of chlorphenesin (CF, 1) and polylactide (2) was developed. It involves addition of chlorphenesin to L-lactide followed by ring-opening polymerization of the latter. The process was optimized by factorial design to maximize the conversion and simultaneously to obtain appropriately high average molecular mass of the prodrug. On the basis of a mathematical model, it is possible to control the length of polymeric chain and, thus to control duration of the therapeutic effect in case of using the prodrug as DDS.
Author Agnieszka Sebai (FC / LTP)
Agnieszka Sebai,,
- Laboratory Of Technological Processes
, Paweł Ruśkowski (FC / LTP)
Paweł Ruśkowski,,
- Laboratory Of Technological Processes
, Vanessa Bijak (FC / LTP)
Vanessa Bijak,,
- Laboratory Of Technological Processes
, Agnieszka Gadomska-Gajadhur (FC / LTP)
Agnieszka Gadomska-Gajadhur,,
- Laboratory Of Technological Processes
, Aleksandra Kruk (FC / LTP)
Aleksandra Kruk,,
- Laboratory Of Technological Processes
, Ludwik Synoradzki (FC / LTP)
Ludwik Synoradzki,,
- Laboratory Of Technological Processes
Journal seriesOrganic Process Research & Development, ISSN 1083-6160, (A 35 pkt)
Issue year2018
Publication size in sheets0.5
Keywords in Englishchlorphenesin, DDS, polylactide, macromolecular prodrug, DOE
ASJC Classification1605 Organic Chemistry; 1606 Physical and Theoretical Chemistry
Abstract in Polishxxx
Languageen angielski
wdpb_publikacje_pliki_plik_publikacja_3381_org.pdf 1.52 MB
Score (nominal)35
ScoreMinisterial score = 35.0, 23-01-2018, ArticleFromJournal
Ministerial score (2013-2016) = 35.0, 23-01-2018, ArticleFromJournal
Publication indicators Scopus SNIP (Source Normalised Impact per Paper): 2017 = 0.978; WoS Impact Factor: 2017 = 3.584 (2) - 2017=3.109 (5); WoS Citations = 2
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* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.