Evaluation of taste masking effect of diclofenac using sweeteners and cyclodextrin by a potentiometric electronic tongue

Joanna Lenik , Małgorzata Wesoły , Patrycja Ciosek , Wojciech Wróblewski

Abstract

In this work a potentiometric electronic tongue based on classical ion-selective electrodes (6 types) and solid contact electrodes (2 types) was applied. The classical electrodes based on PVC membrane with other plasticizers exhibited cation-, anion-, amine-, and carbonate sensitivity, while the solid contact electrodes based on different lipophilic salts established diclofenac sensitivity. These sensors were used to assess the taste masking efficiency of diclofenac using selected sweeteners and cyclodextrin. Various amounts of four sweeteners (namely: sucrose, lactose, acesulfame K, sodium saccharin) as well as 2-hydroxypropyl-β-cyclodextrin were applied to mask the bitter taste of diclofenac. The signals of the sensor array registered during the experiments were processed by the Principal Component Analysis. The results obtained i.e. the chemical images of the samples indicated that the taste masking effect was the most pronounced for cyclodextrin, acesulfame K, sodium saccharin and for sucrose at higher concentration, whereas was almost negligible in the case of the presence of lactose in solution.
Author Joanna Lenik
Joanna Lenik,,
-
, Małgorzata Wesoły ZMB
Małgorzata Wesoły,,
- Department Of Microbioanalytics
, Patrycja Ciosek ZMB
Patrycja Ciosek,,
- Department Of Microbioanalytics
, Wojciech Wróblewski ZMB
Wojciech Wróblewski,,
- Department Of Microbioanalytics
Journal seriesJournal of Electroanalytical Chemistry, ISSN 1572-6657
Issue year2016
Vol780
Pages153-159
Publication size in sheets0.5
Keywords in EnglishElectronic tongue; Ion-selective electrodes; Taste masking; Diclofenac
DOIDOI:10.1016/j.jelechem.2016.09.017
URL http://www.sciencedirect.com/science/article/pii/S1572665716304751
Languageen angielski
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Evaluation of taste masking effect of diclofenac using sweeteners and cyclodextrin by a pptentiometric electronic tongue.pdf 519.76 KB
Score (nominal)35
ScoreMinisterial score = 35.0, 28-11-2017, ArticleFromJournal
Ministerial score (2013-2016) = 35.0, 28-11-2017, ArticleFromJournal
Publication indicators WoS Impact Factor: 2016 = 3.012 (2) - 2016=2.883 (5)
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