Cellular aspects of folate and antifolate membrane transport

A. Brzezińska , Patrycja Wińska , M. Balińska

Abstract

Folates--one carbon carriers--take part in the metabolism of purine, thymidylate and some amino acids. Internalization of these compounds employs several mechanisms of transport systems. Reduced folate carriers and folate receptors play the most important role in this process. The physiological role of these molecules in normal and neoplastic cells is described regarding changes in transport activity and connection of transport systems with resistance to antifolates and cancer development.
Author A. Brzezińska
A. Brzezińska,,
-
, Patrycja Wińska (FC / IBC / DDTB)
Patrycja Wińska,,
- Department Of Drug Technology And Biotechnology
, M. Balińska
M. Balińska,,
-
Journal seriesActa Biochimica Polonica, ISSN 0001-527X
Issue year2000
Vol47
Pages735-749
Keywords in Englishfolates, antifolates, folate carrier, folate receptor, chemotherapy
ASJC Classification1300 General Biochemistry, Genetics and Molecular Biology
Internal identifier4001
Languageen angielski
Score (nominal)15
Score sourcejournalList
Publication indicators WoS Citations = 50; Scopus SNIP (Source Normalised Impact per Paper): 2000 = 0.304; WoS Impact Factor: 2006 = 1.363 (2) - 2007=1.624 (5)
Citation count*75 (2015-04-29)
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* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.
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