Cellular aspects of folate and antifolate membrane transport
A. Brzezińska , Patrycja Wińska , M. Balińska
AbstractFolates--one carbon carriers--take part in the metabolism of purine, thymidylate and some amino acids. Internalization of these compounds employs several mechanisms of transport systems. Reduced folate carriers and folate receptors play the most important role in this process. The physiological role of these molecules in normal and neoplastic cells is described regarding changes in transport activity and connection of transport systems with resistance to antifolates and cancer development.
|Journal series||Acta Biochimica Polonica, ISSN 0001-527X|
|Keywords in English||folates, antifolates, folate carrier, folate receptor, chemotherapy|
|Publication indicators||= 50; : 2000 = 0.304; : 2006 = 1.363 (2) - 2007=1.624 (5)|
|Citation count*||75 (2015-04-29)|
* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.