Polyvinylpyrrolidone (PVP) hydrogel coating for cylindrical polyurethane scaffolds

Aleksandra Kuźmińska , Beata Aleksandra Butruk-Raszeja , Aleksandra Stefanowska , Tomasz Ciach

Abstract

The presented study describes a method for the preparation and modification of cylindrical polyurethane structures with polyvinylpyrrolidone (PVP) hydrogel coating. The modified polyurethane scaffolds were fabricated using the phase-inversion technique and intended to be used as a vascular prosthesis. The proposed modification method involves a two-step Fenton-type reaction. Physicochemical analysis (Fourier transform infrared spectroscopy, scanning electron microscopy) confirmed the presence of the hydrogel coating. The influence of PVP and polymerization initiator (cumene hydroperoxide) concentrations on hydrogel’s properties were examined. The higher concentrations of reagent were used, the thicker coating was obtained. After modification, the material’s surface becomes more hydrophilic in comparison to pristine polyurethane. Cytotoxicity assay (MTT test) confirmed that PVP-coating is not toxic. The introduction of hydrogel coating resulted in a significant decrease in the fibrinogen adsorbed to the material’s surface as compared to a non-modified polymer. Platelet adhesion assay demonstrated almost no platelet adhesion to the modified surfaces.
Author Aleksandra Kuźmińska (FCPE / DBBE)
Aleksandra Kuźmińska,,
- Department of Biotechnology and Bioprocess Engineering
, Beata Aleksandra Butruk-Raszeja (FCPE / DBBE)
Beata Aleksandra Butruk-Raszeja,,
- Department of Biotechnology and Bioprocess Engineering
, Aleksandra Stefanowska (FCPE)
Aleksandra Stefanowska,,
- Faculty of Chemical and Process Engineering
, Tomasz Ciach (FCPE / DBBE)
Tomasz Ciach,,
- Department of Biotechnology and Bioprocess Engineering
Journal seriesColloids and Surfaces B-Biointerfaces, [Colloids and Surfaces B: Biointerfaces], ISSN 0927-7765, e-ISSN 1873-4367
Issue year2020
Vol192
Pages1-6
Publication size in sheets0.5
Article number111066
Keywords in Englishpolyvinylpyrrolidone, polyurethane, hydrogel, vascular graft, coating, biocompatibility
ASJC Classification2700 General Medicine; 1305 Biotechnology; 1505 Colloid and Surface Chemistry; 1606 Physical and Theoretical Chemistry; 3110 Surfaces and Interfaces
DOIDOI:10.1016/j.colsurfb.2020.111066
URL https://reader.elsevier.com/reader/sd/pii/S0927776520302964?token=7E420BFC86DC59C63F1C6392D70291C269C29DADAB38C7A51A34E46EDAC59140995844A55C1D6DAC789565E51882C334
Languageen angielski
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Kuźmińska A. (i in.) - Polyvinylpyrrolidone (PVP) hydrogel...pdf 2.25 MB
Score (nominal)100
Score sourcejournalList
ScoreMinisterial score = 100.0, 10-06-2020, ArticleFromJournal
Publication indicators Scopus Citations = 0; Scopus SNIP (Source Normalised Impact per Paper): 2018 = 1.042; WoS Impact Factor: 2018 = 3.973 (2) - 2018=4.18 (5)
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UwagiThis work was supported by the National Science Centre, project number 2016/21/N/ST8/01953.
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* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.
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