Adaptive Optics (rtx1) High-Resolution Imaging of Photoreceptors and Retinal Arteries in Patients with Diabetic Retinopathy

Anna Zaleska-Żmijewska , Zbigniew M. Wawrzyniak , Anna Dąbrowska , Jacek Paweł Szaflik

Abstract

Background. Diabetic retinopathy (DR) is the leading cause of impaired vision in patients with diabetes mellitus. An adaptive optics retinal camera (rtx1™; Imagine Eyes, France) was used to capture images of cones and retinal arteries from patients with DR.Objective. Cone parameters (density, interphotoreceptor distance, and regularity) and retinal artery parameters (wall thickness, lumen diameter, WLR, and WCSA) were analyzed in 36 patients with nonproliferative DR (NPDR; 22 with mild NPDR and 14 with moderate NPDR) and in 20 healthy volunteers (the control group).Results. Cone density at 2° eccentricities was significantly lower in the DR compared to the control group (19822±4342 cells/mm2vs.24722±3507cells/mm2, respectively). Cone density and regularity decreased with increasing severity of DR. The artery walls were significantly thicker in the DR group. The WLR and WCSA differed significantly between the DR and the control groups (WLR0.339±0.06vs.0.254±0.04; WCSA5567±1140vs.4178±944, respectively).Conclusions. Decreased cone regularity and density are seen in patients with mild and moderate NPDR. Abnormalities of retinal arterioles show signs of arteriolar dysfunction in DR. Retinal image analysis with the rtx1 offers a novel noninvasive measurement of early changes in the neural cells and retina vasculature in diabetic eyes.
Author Anna Zaleska-Żmijewska
Anna Zaleska-Żmijewska,,
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, Zbigniew M. Wawrzyniak (FEIT / PE)
Zbigniew M. Wawrzyniak,,
- The Institute of Electronic Systems
, Anna Dąbrowska
Anna Dąbrowska,,
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, Jacek Paweł Szaflik
Jacek Paweł Szaflik,,
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Journal seriesJournal of Diabetes Research, ISSN 2314-6745, (A 25 pkt)
Issue year2019
Vol2019
Pages1-12
Publication size in sheets0.55
ASJC Classification1310 Endocrinology; 2712 Endocrinology, Diabetes and Metabolism
DOIDOI:10.1155/2019/9548324
URL https://www.hindawi.com/journals/jdr/2019/9548324/cta/
Languageen angielski
File
9548324.pdf 17.15 MB
Score (nominal)25
ScoreMinisterial score = 25.0, 29-06-2019, ArticleFromJournal
Publication indicators WoS Citations = 0; Scopus SNIP (Source Normalised Impact per Paper): 2016 = 0.874; WoS Impact Factor: 2017 = 2.885 (2) - 2017=2.949 (5)
Citation count*1 (2019-08-11)
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* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.
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