Adaptive Optics (rtx1) High-Resolution Imaging of Photoreceptors and Retinal Arteries in Patients with Diabetic Retinopathy

Anna Zaleska-Żmijewska , Zbigniew M. Wawrzyniak , Anna Dąbrowska , Jacek Paweł Szaflik


Background. Diabetic retinopathy (DR) is the leading cause of impaired vision in patients with diabetes mellitus. An adaptive optics retinal camera (rtx1™; Imagine Eyes, France) was used to capture images of cones and retinal arteries from patients with DR.Objective. Cone parameters (density, interphotoreceptor distance, and regularity) and retinal artery parameters (wall thickness, lumen diameter, WLR, and WCSA) were analyzed in 36 patients with nonproliferative DR (NPDR; 22 with mild NPDR and 14 with moderate NPDR) and in 20 healthy volunteers (the control group).Results. Cone density at 2° eccentricities was significantly lower in the DR compared to the control group (19822±4342 cells/mm2vs.24722±3507cells/mm2, respectively). Cone density and regularity decreased with increasing severity of DR. The artery walls were significantly thicker in the DR group. The WLR and WCSA differed significantly between the DR and the control groups (WLR0.339±0.06vs.0.254±0.04; WCSA5567±1140vs.4178±944, respectively).Conclusions. Decreased cone regularity and density are seen in patients with mild and moderate NPDR. Abnormalities of retinal arterioles show signs of arteriolar dysfunction in DR. Retinal image analysis with the rtx1 offers a novel noninvasive measurement of early changes in the neural cells and retina vasculature in diabetic eyes.
Author Anna Zaleska-Żmijewska - [Medical University of Warsaw]
Anna Zaleska-Żmijewska,,
, Zbigniew M. Wawrzyniak (FEIT / PE)
Zbigniew M. Wawrzyniak,,
- The Institute of Electronic Systems
, Anna Dąbrowska - [Samodzielny Publiczny Kliniczny Szpital Okulistyczny]
Anna Dąbrowska,,
, Jacek Paweł Szaflik - [Medical University of Warsaw]
Jacek Paweł Szaflik,,
Journal seriesJournal of Diabetes Research, ISSN 2314-6745, (N/A 70 pkt)
Issue year2019
Publication size in sheets0.55
ASJC Classification1310 Endocrinology; 2712 Endocrinology, Diabetes and Metabolism
Languageen angielski
9548324.pdf 17.15 MB
Score (nominal)70
Score sourcejournalList
ScoreMinisterial score = 70.0, 13-12-2019, ArticleFromJournal
Publication indicators WoS Citations = 0; Scopus Citations = 0; Scopus SNIP (Source Normalised Impact per Paper): 2018 = 1.075; WoS Impact Factor: 2018 = 3.04 (2) - 2018=3.233 (5)
Citation count*2 (2020-01-06)
Share Share

Get link to the record

* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.
Are you sure?