Cell outer membrane mimetic surface as a material with improved hemocompatibility

Maciej Trzaskowski , Beata Aleksandra Butruk , Tomasz Ciach

Abstract

The phenomenon of blood coagulation on the surfaces of implantable devices such as artifi cial blood vessels, valves or hearts is the major problem that has to be taken into consideration during the construction of such devices. Since the main factor that has an infl uence on clotting of blood is the surface of the material the device is made of, numerous attempts has already been undertaken to modify surfaces of existing materials in order to provide necessary protection against clot formation, very often by coating the materials with bio-active substances. Th e aim of presented study was to create a coating of phosphatidylcholine that would mimic natural cell outer membrane on the surface of polyurethane — a material already in use in construction of cardiovascular implants. Th e obtained coated materials have been evaluated with the use of FT-IR/ATR spectroscopy. Th e change in contact angle of modifi ed material was also investigated. Finally in vitro cytotoxicity tests were performed in order to examine biocompatibility of obtained material.
Author Maciej Trzaskowski (FCPE / DBBE)
Maciej Trzaskowski ,,
- Department of Biotechnology and Bioprocess Engineering
, Beata Aleksandra Butruk (FCPE / DBBE)
Beata Aleksandra Butruk,,
- Department of Biotechnology and Bioprocess Engineering
, Tomasz Ciach (FCPE / DBBE)
Tomasz Ciach,,
- Department of Biotechnology and Bioprocess Engineering
Journal seriesChallenges of Modern Technology, ISSN 2082-2863, e-ISSN 2353-4419, (B 2 pkt)
Issue year2011
Vol2
No4
Pages7-10
Keywords in Englishphosphatidylcholine, polyurethane, cell outer membrane mimetic surface, artifi cial heart
URL http://nas.isep.pw.edu.pl/kok/journal/index.php/isuues/file/60-cell-outer-membrane-mimetic-surface-as-a-material-with-improved-hemocompatibility
Languageen angielski
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