Continuous cerebrovascular reactivity monitoring in moderate/severe traumatic brain injury: a narrative review of advances in neurocritical care

Frederick A. Zeiler , Ari Ercole , Marek Czosnyka , Peter Smielewski , Gregory Hawryluk , P. J Hutchinson , D.K. Menon , Marcel Aries

Abstract

Impaired cerebrovascular reactivity in adult moderate and severe traumatic brain injury (TBI) is known to be associated with worse global outcome at 6–12 months. As technology has improved over the past decades, monitoring of cerebrovascular reactivity has shifted from intermittent measures, to experimentally validated continuously updating indices at the bedside. Such advances have led to the exploration of individualised physiologic targets in adult TBI management, such as optimal cerebral perfusion pressure (CPP) values, or CPP limits in which vascular reactivity is relatively intact. These targets have been shown to have a stronger association with outcome compared with existing consensus-based guideline thresholds in severe TBI care. This has sparked ongoing prospective trials of such personalised medicine approaches in adult TBI. In this narrative review paper, we focus on the concept of cerebral autoregulation, proposed mechanisms of control and methods of continuous monitoring used in TBI. We highlight multimodal cranial monitoring approaches for continuous cerebrovascular reactivity assessment, physiologic and neuroimaging correlates, and associations with outcome. Finally, we explore the recent ‘state-of-the-art’ advances in personalised physiologic targets based on continuous cerebrovascular reactivity monitoring, their benefits, and implications for future avenues of research in TBI.

Author Frederick A. Zeiler - [Rady Faculty of Health Sciences]
Frederick A. Zeiler,,
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, Ari Ercole - [University of Cambridge]
Ari Ercole,,
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, Marek Czosnyka (FEIT / PE)
Marek Czosnyka,,
- The Institute of Electronic Systems
, Peter Smielewski
Peter Smielewski,,
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, Gregory Hawryluk - [Rady Faculty of Health Sciences]
Gregory Hawryluk,,
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, P. J Hutchinson
P. J Hutchinson,,
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, D.K. Menon
D.K. Menon,,
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, Marcel Aries - [University Hospital Maastricht]
Marcel Aries,,
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Journal seriesBritish Journal of Anaesthesia, ISSN 0007-0912, e-ISSN 1471-6771
Issue year2020
Vol124
Pages440-453
ASJC Classification2703 Anesthesiology and Pain Medicine
DOIDOI:10.1016/j.bja.2019.11.031
URL https://bjanaesthesia.org/action/showPdf?pii=S0007-0912%2819%2930966-3
Languageen angielski
File
M.Czosnyka_Continuous cerebrovascular reactivity.pdf 1.25 MB
Score (nominal)140
Score sourcejournalList
ScoreMinisterial score = 140.0, 21-07-2020, ArticleFromJournal
Publication indicators Scopus Citations = 0; Scopus SNIP (Source Normalised Impact per Paper): 2018 = 1.836; WoS Impact Factor: 2018 = 6.199 (2) - 2018=6.522 (5)
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