Improvement of the bio-functional properties of TiO2 nanotubes
Agata Roguska , Marcin Pisarek , A. Belcarz , L. Marcon , M. Hołdyński , Mariusz Andrzejczuk , Maria Janik-Czachor
AbstractTitanium oxide nanotubes with diameters from ca. 40–120 nm fabricated by the anodic oxidation of Ti ata constant voltage (10–28 V) were investigated to identify factors improving their bio-functional prop-erties. Prepared substrates were subsequently annealed at 450◦C and 650◦C to obtain nanotubes havinga crystalline structure, and were then examined by SEM, XRD, XPS, BET and contact angle measure-ment techniques. The thermally stabilized surfaces were subjected to bidirectional functionalization: bydeposition of a thin layer of Ca-P and by loading with silver nanoparticles. Three factors were found topromote the proliferation of osteoblast (U2OS) cells: a larger nanotube diameter, a higher annealing tem-perature, and the presence of a thin Ca-P layer. Differentiation of these cells (by ALP test) was stimulatedby a higher (650◦C) nanotube annealing temperature, but not by a thin Ca-P layer. The TiO2nanotubes-modified samples exhibited noticeable antibacterial properties. Moreover, the additional deposition ofAg nanoparticles almost completely inhibited the survivability of S. epidermidis cells beyond 3 h of con-tact. In conclusion, TiO2nanotubes-modified surfaces exhibit distinct bone forming ability and significantantibacterial properties, and can be easily functionalized by a thin Ca-P layer or nano-Ag deposition forfurther improvement of the above functionalities.
|Journal series||Applied Surface Science, ISSN 0169-4332|
|Publication size in sheets||0.5|
|Keywords in English||Titanium oxide nanotubes (TiO2NT), Surface characterization methods, Bone forming ability, Bioactivity, Antibacterial properties|
|Score|| = 35.0, 28-11-2017, ArticleFromJournal|
= 35.0, 28-11-2017, ArticleFromJournal
|Publication indicators||: 2016 = 3.387 (2) - 2016=3.184 (5)|
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