Improvement of the bio-functional properties of TiO2 nanotubes

Agata Roguska , Marcin Pisarek , A. Belcarz , L. Marcon , M. Hołdyński , Mariusz Andrzejczuk , Maria Janik-Czachor

Abstract

Titanium oxide nanotubes with diameters from ca. 40–120 nm fabricated by the anodic oxidation of Ti ata constant voltage (10–28 V) were investigated to identify factors improving their bio-functional prop-erties. Prepared substrates were subsequently annealed at 450◦C and 650◦C to obtain nanotubes havinga crystalline structure, and were then examined by SEM, XRD, XPS, BET and contact angle measure-ment techniques. The thermally stabilized surfaces were subjected to bidirectional functionalization: bydeposition of a thin layer of Ca-P and by loading with silver nanoparticles. Three factors were found topromote the proliferation of osteoblast (U2OS) cells: a larger nanotube diameter, a higher annealing tem-perature, and the presence of a thin Ca-P layer. Differentiation of these cells (by ALP test) was stimulatedby a higher (650◦C) nanotube annealing temperature, but not by a thin Ca-P layer. The TiO2nanotubes-modified samples exhibited noticeable antibacterial properties. Moreover, the additional deposition ofAg nanoparticles almost completely inhibited the survivability of S. epidermidis cells beyond 3 h of con-tact. In conclusion, TiO2nanotubes-modified surfaces exhibit distinct bone forming ability and significantantibacterial properties, and can be easily functionalized by a thin Ca-P layer or nano-Ag deposition forfurther improvement of the above functionalities.
Author Agata Roguska - [Institute of Physical Chemistry Polish Academy of Sciences (IChF PAN)]
Agata Roguska,,
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- Instytut Chemii Fizycznej Polskiej Akademii Nauk
, Marcin Pisarek - Institute of Physical Chemistry Polish Academy of Sciences (IChF PAN)
Marcin Pisarek,,
-
, A. Belcarz
A. Belcarz,,
-
, L. Marcon
L. Marcon,,
-
, M. Hołdyński
M. Hołdyński,,
-
, Mariusz Andrzejczuk ZPM
Mariusz Andrzejczuk,,
- Division of Materials Design
, Maria Janik-Czachor
Maria Janik-Czachor,,
-
Journal seriesApplied Surface Science, ISSN 0169-4332
Issue year2016
No388
Pages775-785
Publication size in sheets0.5
Keywords in EnglishTitanium oxide nanotubes (TiO2NT), Surface characterization methods, Bone forming ability, Bioactivity, Antibacterial properties
DOIDOI:10.1016/j.apsusc.2016.03.128
Languageen angielski
Score (nominal)35
ScoreMinisterial score = 35.0, 28-11-2017, ArticleFromJournal
Ministerial score (2013-2016) = 35.0, 28-11-2017, ArticleFromJournal
Publication indicators WoS Impact Factor: 2016 = 3.387 (2) - 2016=3.184 (5)
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