Improvement of the bio-functional properties of TiO2 nanotubes

Agata Roguska , Marcin Pisarek , A. Belcarz , L. Marcon , M. Hołdyński , Mariusz Andrzejczuk , Maria Janik-Czachor


Titanium oxide nanotubes with diameters from ca. 40–120 nm fabricated by the anodic oxidation of Ti ata constant voltage (10–28 V) were investigated to identify factors improving their bio-functional prop-erties. Prepared substrates were subsequently annealed at 450◦C and 650◦C to obtain nanotubes havinga crystalline structure, and were then examined by SEM, XRD, XPS, BET and contact angle measure-ment techniques. The thermally stabilized surfaces were subjected to bidirectional functionalization: bydeposition of a thin layer of Ca-P and by loading with silver nanoparticles. Three factors were found topromote the proliferation of osteoblast (U2OS) cells: a larger nanotube diameter, a higher annealing tem-perature, and the presence of a thin Ca-P layer. Differentiation of these cells (by ALP test) was stimulatedby a higher (650◦C) nanotube annealing temperature, but not by a thin Ca-P layer. The TiO2nanotubes-modified samples exhibited noticeable antibacterial properties. Moreover, the additional deposition ofAg nanoparticles almost completely inhibited the survivability of S. epidermidis cells beyond 3 h of con-tact. In conclusion, TiO2nanotubes-modified surfaces exhibit distinct bone forming ability and significantantibacterial properties, and can be easily functionalized by a thin Ca-P layer or nano-Ag deposition forfurther improvement of the above functionalities.
Author Agata Roguska - [Institute of Physical Chemistry Polish Academy of Sciences (IChF PAN)]
Agata Roguska,,
- Instytut Chemii Fizycznej Polskiej Akademii Nauk
, Marcin Pisarek - Institute of Physical Chemistry Polish Academy of Sciences (IChF PAN)
Marcin Pisarek,,
, A. Belcarz
A. Belcarz,,
, L. Marcon
L. Marcon,,
, M. Hołdyński
M. Hołdyński,,
, Mariusz Andrzejczuk ZPM
Mariusz Andrzejczuk,,
- Division of Materials Design
, Maria Janik-Czachor
Maria Janik-Czachor,,
Journal seriesApplied Surface Science, ISSN 0169-4332
Issue year2016
Publication size in sheets0.5
Keywords in EnglishTitanium oxide nanotubes (TiO2NT), Surface characterization methods, Bone forming ability, Bioactivity, Antibacterial properties
Languageen angielski
Score (nominal)35
ScoreMinisterial score = 35.0, 28-11-2017, ArticleFromJournal
Ministerial score (2013-2016) = 35.0, 28-11-2017, ArticleFromJournal
Publication indicators WoS Impact Factor: 2016 = 3.387 (2) - 2016=3.184 (5)
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* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.