Mixing and fluid dynamics effects in particle precipitation processes

Jerzy Robert Bałdyga


Precipitation defined as the rapid formation of moderately soluble crystalline or amorphous solid particles from a liquid solution under high supersaturation conditions is considered. It involves the simultaneous and fast occurrence of primary nucleation and growth of particles together with the secondary processes such as aggregation and breakage. It is shown how the effects of fluid low and mixing affect the subprocesses forming the overall precipitation process. Examples are presented for reactive precipitation and antisolvent precipitation with supercritical fluids applied as the antisolvents. The elementary subprocesses forming the overall precipitation process (i.e. macro-, meso-, micromixing, chemical reaction, nucleation and growth of particles, aggregation and breakage) are characterized by the related time constants and the application of time constants in the modeling and scale-up of precipitation processes is presented. The effects of turbulence on particle formation are simulated using mechanistic models, CFD and population balances (including the method of moments and the quadrature method of moments). The results of modeling are compared with experimental data. Finally, it is shown in the context of practical applications to what extent the approaches discussed in this paper can be applied to "design" particles.
Author Jerzy Robert Bałdyga (FCPE / DCRED)
Jerzy Robert Bałdyga,,
- Department of Chemical Reactor Engineering and Dynamics
Journal seriesKONA Powder and Particle Journal, ISSN 0288-4534
Issue year2016
Publication size in sheets1.1
Keywords in Englishaggregation, breakage, fluid dynamics, mixing, population balance, precipitation
ASJC Classification2200 General Engineering; 2500 General Materials Science; 1500 General Chemical Engineering; 1600 General Chemistry
URL https://www.kona.or.jp/jp/journal/pdf/2016/08_33_2016.pdf
Languageen angielski
Bałdyga J. - Mixing and fluid....pdf 3.71 MB
Score (nominal)25
ScoreMinisterial score = 25.0, 05-09-2019, ArticleFromJournal
Ministerial score (2013-2016) = 25.0, 05-09-2019, ArticleFromJournal
Publication indicators WoS Citations = 2; Scopus SNIP (Source Normalised Impact per Paper): 2016 = 0.812; WoS Impact Factor: 2016 = 1.683 (2) - 2016=1.518 (5)
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* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.
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