Investigating of substance transport in simulated biomedical systems

Anna Adach , Andrzej Skassa , Natalia Kister , Aleksandra Bugalska

Abstract

The investigations deal with the mass transfer in simulated biomedical systems. The self-designed Sequential Unit (SU) system imitated different biomedical setups, boundary conditions. The experiments simulated: diffusion chamber (also with two barriers), the transport through the membrane to the blood stream, transport from the stent eluting drug simultaneously to the vessels cells and to the blood stream. The concentrations of substances and the relative mass increases/decreases for SU systems indicate that the order of the curves follows the order of mass transfer resistances. The strong dependence of mass transfer rates versus concentration and type of diffusing substance was confirmed. The calculated drug fluxes, diffusion coefficients, permeation coefficients are convergent with literature. The permeation coefficients for the complex sequential systems can be estimated as the parallel connexion of constituent coefficients. The experiments approved functionality of the SU for investigations in simulated biomedical system. The obtained data were used for numerical verification.
Author Anna Adach (FCPE / DPKT)
Anna Adach,,
- Department of Process Kinetics and Thermodynamics
, Andrzej Skassa (FCPE)
Andrzej Skassa,,
- Faculty of Chemical and Process Engineering
, Natalia Kister
Natalia Kister,,
-
, Aleksandra Bugalska (FCPE)
Aleksandra Bugalska,,
- Faculty of Chemical and Process Engineering
Pages19-29
Publication size in sheets0.5
Book The 22nd Polish Conference of Chemical and Process Engineering: Proceedings, 2016, Faculty of Process and Environmental Engineering, ISBN 978-83-61997-75-7, 1584 p.
Proceedings OKIChiP 2016.pdf / No licence information (file archived - login or check accessibility on faculty)
Keywords in Englishdrug release, substance transfer, diffusion chamber, biomedical systems
Languageen angielski
Score (nominal)0
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