Effect of liquid properties and aerosol dilution conditions on the final droplet size of aerosol delivered from nebulizers
- Katarzyna Ewa Dobrowolska,
- Małgorzata Matyśkiewicz,
- Tomasz Robert Sosnowski
Nebulizers are medical devices, which disperse pharmaceutical liquids to fine droplets for inhalation (aerosol therapy). Such droplets with diameter below 5 μm can penetrate to the lowest parts of human lungs and deposit on the surface of lungs. Deposition areas and hence the efficiency of aerosol therapy are strongly influenced by many factors, i.e.: geometry of the respiratory system, individual respiratory parameters and the properties of aerosol which are related to the physicochemical properties of the liquid drug. Optimization of these parameters and better understanding of their impact on droplet size distribution in the aerosol cloud can improve the effectiveness of the therapy. The aim of this study was to investigate the influence of: (i) physicochemical properties (i.e., surface tension, viscosity and conductivity) of selected reference liquids, and (ii) properties and amount of external air which dilutes the aerosol during inhalation from nebulizers (i.e. air temperature and humidity) on the characteristics of the aerosol (droplet size distribution and mass output). Aerosol parameters were measured, among others, by laser diffraction with the simultaneous monitoring the external conditions of air admixed to the clouds emitted from jet (Pari Boy) and mesh (Intec Twister) nebulizers. The results show that the surface tension and viscosity of atomized liquid change the droplet size distribution of aerosol. The principle of operation of a given nebulizer (jet or mesh) also strongly influence the characteristics of aerosol. The effect of diluting was noted. To conclude, the variation in aerosol parameters measured in this study being the result of liquid properties and different conditions of aerosol dilution, show the importance of tested factors on predicted drug deposition in the lungs. Therefore, these factors should be taken into account in the optimization of drug nebulization process for inhalation therapy.
- Record ID
- Publication type
- Article number
- EYEC Monograph: 9th European Young Engineers Conference, 2021, Warszawa, Politechnika Warszawska, Wydział Inżynierii Chemicznej i Procesowej, 183 p., ISBN 978-83-936575-9-9
- Keywords in English
- nebulization, droplet size distribution, atomization conditions, therapeutic aerosol
- Related project
- [2018/29/B/ST8/00273] Procesy atomizacji cieczy do celowanego wprowadzania leków do układu oddechowego - mechanizmy powstawania, transportu i depozycji kropel.. . Project leader at WUT: Tomasz Robert Sosnowski,
+48 22 234 62 78, start date 30-05-2019, end date 29-05-2022, in run
Projects financed by NSC [Projekty finansowane przez NCN]
- eng (en) English
- Score (nominal)
- Additional fields
- Uwagi: The work was supported by National Science Centre (grant no. 2018/29/B/ST8/00273).
- Uniform Resource Identifier
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