Pressure Reactivity-Based Optimal Cerebral Perfusion Pressure in a Traumatic Brain Injury Cohort

J. Donnelly , Marek Czosnyka , H. Adams , C. Robba , L. A Steiner , D. Cardim , B. Cabella , X. Liu , A. Ercole , P. J Hutchinson , D. K Menon , M.J.H. Aries , Peter Smielewski

Abstract

Objectives: Retrospective data from patients with severe traumatic brain injury (TBI) indicate that deviation from the continuously calculated pressure reactivity-based “optimal” cerebral perfusion pressure (CPPopt) is associated with worse patient outcome. The objective of this study was to assess the relationship between prospectively collected CPPopt data and patient outcome after TBI. Methods: We prospectively collected intracranial pressure (ICP) monitoring data from 231 patients with severe TBI at Addenbrooke’s Hospital, UK. Uncleaned arterial blood pressure and ICP signals were recording using ICM+® software on dedicated bedside computers. CPPopt was determined using an automatic curve fitting procedure of the relationship between pressure reactivity index (PRx) and CPP using a 4-h window, as previously described. The difference between an instantaneous CPP value and its corresponding CPPopt value was denoted every minute as ΔCPPopt. A negative ΔCPPopt that was associated with impaired PRx (>+0.15) was denoted as being below the lower limit of reactivity (LLR). Glasgow Outcome Scale (GOS) score was assessed at 6 months post-ictus. Results: When ΔCPPopt was plotted against PRx and stratified by GOS groupings, data belonging to patients with a more unfavourable outcome had a U-shaped curve that shifted upwards. More time spent with a ΔCPPopt value below the LLR was positively associated with mortality (area under the receiver operating characteristic curve = 0.76 [0.68–0.84]). Conclusions: In a recent cohort of patients with severe TBI, the time spent with a CPP below the CPPopt-derived LLR is related to mortality. Despite aggressive CPP- and ICP-oriented therapies, TBI patients with a fatal outcome spend a significant amount of time with a CPP below their individualised CPPopt, indicating a possible therapeutic target.
Author J. Donnelly - [University of Cambridge]
J. Donnelly,,
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, Marek Czosnyka (FEIT / PE)
Marek Czosnyka,,
- The Institute of Electronic Systems
, H. Adams - [University of Cambridge]
H. Adams,,
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, C. Robba - [University of Cambridge]
C. Robba,,
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, L. A Steiner - [Universitätsspital Basel]
L. A Steiner,,
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, D. Cardim - [University of Cambridge]
D. Cardim,,
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, B. Cabella - [University of Cambridge]
B. Cabella,,
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, X. Liu - [University of Cambridge]
X. Liu,,
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, A. Ercole - [University of Cambridge]
A. Ercole,,
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, P. J Hutchinson - [University of Cambridge]
P. J Hutchinson,,
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et al.`
Journal seriesActa Neurochirurgica, Supplement, ISSN 0065-1419, (0 pkt)
Issue year2018
Vol126
Pages209-212
Publication size in sheets0.5
Keywords in EnglishTraumatic brain injury; Intracranial pressure; Cerebral hemodynamics; Autoregulation; Cerebral perfusion pressure
ASJC Classification2728 Clinical Neurology; 2746 Surgery
DOIDOI:10.1007/978-3-319-65798-1_43
URL https://link.springer.com/chapter/10.1007%2F978-3-319-65798-1_43
Languageen angielski
Score (nominal)0
ScoreMinisterial score = 0.0, 29-04-2019, ArticleFromJournal
Ministerial score (2013-2016) = 5.0, 26-03-2019, ArticleFromJournal - czasopismo zagraniczne spoza list
Publication indicators Scopus Citations = 2; WoS Citations = 0; Scopus SNIP (Source Normalised Impact per Paper): 2017 = 0.44
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* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.
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