Recovery of an antidepressant from pharmaceutical wastes using ionic liquid-based aqueous biphasic systems

Maciej Zawadzki , Francisca A. e Silva , Urszula Domańska-Żelazna , Joao A.P. Coutinho , Sonia P.M. Ventura

Abstract

This study is aimed at developing a sustainable process for the recovery of valuable drugs from pharmaceutical wastes using ionic liquid (IL)-based aqueous biphasic systems (ABS). Because in pharmaceutical wastes, excipients represent the major contaminants, the search for selective routes for their elimination is of primordial relevance and for that purpose IL-based ABS were evaluated. The effects of different process parameters, namely the IL nature, pH and mixture composition used in the extraction system, were studied and the process was optimized to maximize the extraction of the antidepressant from pharmaceutical wastes. Moreover, the maximum amount of amitriptyline able to be processed using such systems was assessed. The set of ABS investigated herein revealed a high extraction performance, as indicated by the outstanding logarithmic functions of the amitriptilyne partition coefficients ranging from 2.41 ± 0.05 to >2.5 and extraction efficiencies between 66% ± 1% and 100%. The best ABS and conditions were considered in the development of an integrated multi-step purification process. The process here proposed comprises three main stages as follows: the solid–liquid extraction of the antidepressant from ADT 25 pills, its purification using the optimal IL-based ABS and the antidepressant isolation by precipitation with anti-solvent. After the removal of most water insoluble excipients in the first step, with the selected IL-based ABS, it was possible to further eliminate water soluble contaminants. A high capability of extraction and purification, leading to the selective separation of amitriptyline hydrochloride from the main contaminants contained in solid pharmaceutical wastes was achieved. Finally, the isolation of the amitriptilyne in a pure state was successfully accomplished through precipitation with the anti-solvent.
Author Maciej Zawadzki ZChF
Maciej Zawadzki,,
- Department Of Physical Chemistry
, Francisca A. e Silva
Francisca A. e Silva,,
-
, Urszula Domańska-Żelazna ZChF
Urszula Domańska-Żelazna,,
- Department Of Physical Chemistry
, Joao A.P. Coutinho
Joao A.P. Coutinho,,
-
, Sonia P.M. Ventura
Sonia P.M. Ventura,,
-
Journal seriesGreen Chemistry, ISSN 1463-9262
Issue year2016
Vol18
No12
Pages3527-3536
Publication size in sheets0.5
DOIDOI:10.1039/C5GC03052H
URL http://pubs.rsc.org/en/content/articlelanding/2016/gc/c5gc03052h#!divAbstract
Languageen angielski
File
c5gc03052h.pdf (file archived - login or check accessibility on faculty) c5gc03052h.pdf 4.34 MB
Score (nominal)45
ScoreMinisterial score = 45.0, 28-11-2017, ArticleFromJournal
Ministerial score (2013-2016) = 45.0, 28-11-2017, ArticleFromJournal
Publication indicators WoS Impact Factor: 2016 = 9.125 (2) - 2016=8.815 (5)
Citation count*0
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* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.
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