A multi-residue analysis of sulphonamides in edible animal tissues using QuEChERS extraction and HPLC-MS/MS

Hiba Abdallah , Carine Arnaudguilhem , Ryszard Łobiński , Farouk Jaber


A HPLC double reaction monitoring MS/MS method was developed for the determination of a wide range (>20) of sulphonamide residues in several edible animal (sheep, pork, beef, chicken and dromedary) tissues. Sample preparation was based on the simultaneous extraction into acetonitrile solution followed by a clean-up using primary secondary amine beads. Quantification was carried out using matrix-matched calibration curves. The limit of detection (LOD) and limit of quantification (LOQ) ranged from 0.5 to 14.5 μg kg−1 and from 1.8 to 48.4 μg kg−1, respectively. The decision limit (CCα) and decision capability (CCβ) obtained were below 100 μg kg−1 for sulphonamides and below 5 μg kg−1 for dapsone. The method was validated in terms of recoveries and inter- and intra-day precision by reference analyses of meat samples using LC-Orbitrap MS and by the analysis of a reference material. The method was applied to the analysis of several animal tissue samples collected in Lebanon. The highest values were observed for sulfamethazine and sulfadimethoxine at 70.2 and 62.5 μg kg−1 in sheep tissues.
Author Hiba Abdallah
Hiba Abdallah,,
, Carine Arnaudguilhem
Carine Arnaudguilhem,,
, Ryszard Łobiński (FC / CAC)
Ryszard Łobiński,,
- Chair Of Analytical Chemistry
, Farouk Jaber
Farouk Jaber,,
Journal seriesAnalytical Methods, ISSN 1759-9660, (A 25 pkt)
Issue year2015
Publication size in sheets0.5
ASJC Classification2200 General Engineering; 1500 General Chemical Engineering; 1602 Analytical Chemistry
URL http://pubs.rsc.org/en/Content/ArticleLanding/2015/AY/C4AY01727G#!divAbstract
Languageen angielski
wdpb_publikacje_pliki_plik_publikacja_2475_org.pdf 687.11 KB
Score (nominal)25
ScoreMinisterial score = 25.0, 10-03-2019, ArticleFromJournal
Ministerial score (2013-2016) = 25.0, 10-03-2019, ArticleFromJournal
Publication indicators Scopus SNIP (Source Normalised Impact per Paper): 2017 = 0.628; WoS Impact Factor: 2015 = 1.915 (2) - 2015=1.906 (5)
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