The factor VIII protein and its function
Anna Mazurkiewicz-Pisarek , Grażyna Płucienniczak , Tomasz Ciach , Andrzej Plucienniczak
AbstractFactor VIII (FVIII), an essential blood coagulation protein, is a key component of the fluid phase blood coagulation system. Human factor VIII is a single chain of about 300 kDa consisting of domains described as A1-A2-B-A3-C1-C2. The protein undergoes processing prior to secretion into blood resulting in a heavy chain of 200 kDa (A1-A2-B) and a light chain of 80 kDa (A3-C1-C2) linked by metal ions. The role of factor VIII is to increase the catalytic efficiency of factor IXa in the activation of factor X. Variants of these factors lead frequently also to severe bleeding disorders.
|Journal series||Acta Biochimica Polonica, ISSN 0001-527X|
|Publication size in sheets||0.5|
|Keywords in English||factor VIII (FVIII), molecular structure, function, hemophilia A, bleeding disorders|
|Score|| = 15.0, 28-11-2017, ArticleFromJournal|
= 15.0, 28-11-2017, ArticleFromJournal
|Publication indicators||: 2016 = 1.159 (2) - 2016=1.491 (5)|
|Citation count*||2 (2018-02-21)|
* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.