The factor VIII protein and its function

Anna Mazurkiewicz-Pisarek , Grażyna Płucienniczak , Tomasz Ciach , Andrzej Plucienniczak

Abstract

Factor VIII (FVIII), an essential blood coagulation protein, is a key component of the fluid phase blood coagulation system. Human factor VIII is a single chain of about 300 kDa consisting of domains described as A1-A2-B-A3-C1-C2. The protein undergoes processing prior to secretion into blood resulting in a heavy chain of 200 kDa (A1-A2-B) and a light chain of 80 kDa (A3-C1-C2) linked by metal ions. The role of factor VIII is to increase the catalytic efficiency of factor IXa in the activation of factor X. Variants of these factors lead frequently also to severe bleeding disorders.
Author Anna Mazurkiewicz-Pisarek
Anna Mazurkiewicz-Pisarek,,
-
, Grażyna Płucienniczak
Grażyna Płucienniczak,,
-
, Tomasz Ciach ZBIB
Tomasz Ciach,,
- Department of Biotechnology and Bioprocess Engineering
, Andrzej Plucienniczak
Andrzej Plucienniczak,,
-
Journal seriesActa Biochimica Polonica, ISSN 0001-527X
Issue year2016
Vol63
No1
Pages11-16
Publication size in sheets0.5
Keywords in Englishfactor VIII (FVIII), molecular structure, function, hemophilia A, bleeding disorders
DOIDOI:10.18388/abp.2015_1056
URL http://www.actabp.pl/pdf/1_2016/2015_1056.pdf
Languageen angielski
File
Mazurkiewicz-Pisarek A. (i in.) - The factor VIII protein....pdf (file archived - login or check accessibility on faculty) Mazurkiewicz-Pisarek A. (i in.) - The factor VIII protein....pdf 523.27 KB
Score (nominal)15
ScoreMinisterial score = 15.0, 28-11-2017, ArticleFromJournal
Ministerial score (2013-2016) = 15.0, 28-11-2017, ArticleFromJournal
Publication indicators WoS Impact Factor: 2016 = 1.159 (2) - 2016=1.491 (5)
Citation count*2 (2018-02-21)
Cite
Share Share



* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.
Back