Patient specific implants for jawbone reconstruction after tumor resection

Roman Major , Piotr Kowalczyk , Marcin Surmiak , Ilona Łojszczyk , Rafał Kamil Podgórski , Paulina Anna Trzaskowska , Tomasz Ciach , Guenter Russmueller , Katarzyna Kasperkiewicz , Major Łukasz , Robert Jabłoński , Jacek Kropiwnicki , Juergen M. Lackner

Abstract

In case of benign and malignant tumours affecting the maxillofacial region, the resection of jawbone reflects the standard therapy in more than 5.000 cases per year within the European Union. The resulting large bone defects lead to scarred, mangled facial appearance, loss of mastication and probably speech, requiring aesthetic and functional surgery as a basis for physical and physiological rehabilitation. Although autologous vascularized bone autografts reflect the current golden standard, the portion of bone available for the procedure is limited and subsequent high-dose anti-cancer chemo-/radiotherapy can lead to local tissue necrosis. Autologous vascularized bone from fibular or iliac-crest autografts is current golden standard in jawbone resection post-treatment, however, the portion of transplantable bone is limited and subsequent high-dose anti-cancer chemo-/radiotherapy often results in tissue necrosis Our research focuses on alternative treatment techniques: tissue reconstruction via novel patient-specifically manufactured maxillofacial implant that stimulates bone tissue growth. The planned neoformation of vascularized bone in such implants within the patient’s own body as “bioreactor” is the safest approach in tissue engineering. The works described herein included the design of the metallic substrate of the implant with the use of computed tomography basing on real patients scans and then 3D-printing the substrates from the Ti6Al7Nb powder. The metal core was then evaluated in terms of structural characteristic, cytotoxicity and gene expression through the in vitro tests. Further experiments were focused on fabrication of the biocompatible coating for outer surface of the bone implant that would enhance the healing process and accelerate the tissue growth. Functional polymeric granulate dedicated for osteoconductive, osteoinductive and osteogenesis properties were elaborated. Another approach including the coating for the implant surface with two-phase biocompatible layer including polymeric microspheres and hydrogel carrier, which would provide long-time release of bone and cartilage growth factors around the implant were also done. The polymeric granulate containing βTCP improved bone cells growth, but it some modification has to be done in order to improve structural pores to ensure for better osteoconductivity. The biocompatible coating including PVP hydrogel and polymeric microspheres is still in the development process.
Author Roman Major - Instytut Metalurgii i Inżynierii Materiałowej im. Aleksandra Krupkowskiego Polskiej Akademii Nauk (IMIM) [Polish Academy of Sciences (PAN)]
Roman Major,,
-
, Piotr Kowalczyk (FCPE / DBBE)
Piotr Kowalczyk,,
- Department of Biotechnology and Bioprocess Engineering
, Marcin Surmiak
Marcin Surmiak,,
-
, Ilona Łojszczyk (FCPE / DBBE)
Ilona Łojszczyk,,
- Department of Biotechnology and Bioprocess Engineering
, Rafał Kamil Podgórski (FCPE / DBBE)
Rafał Kamil Podgórski,,
- Department of Biotechnology and Bioprocess Engineering
, Paulina Anna Trzaskowska (CAMT)
Paulina Anna Trzaskowska,,
- The Centre for Advanced Materials and Technologies
, Tomasz Ciach (FCPE / DBBE)
Tomasz Ciach,,
- Department of Biotechnology and Bioprocess Engineering
, Guenter Russmueller
Guenter Russmueller,,
-
, Katarzyna Kasperkiewicz
Katarzyna Kasperkiewicz,,
-
, Major Łukasz
Major Łukasz,,
-
et al.`
Journal seriesColloids and Surfaces B-Biointerfaces, [Colloids and Surfaces B: Biointerfaces], ISSN 0927-7765, e-ISSN 1873-4367
Issue year2020
Vol193
Pages1-10
Article number111056
Keywords in Englishpatient specific 3D implants, biomaterials, cytotoxicity, microstructure
ASJC Classification2700 General Medicine; 1305 Biotechnology; 1505 Colloid and Surface Chemistry; 1606 Physical and Theoretical Chemistry; 3110 Surfaces and Interfaces
DOIDOI:10.1016/j.colsurfb.2020.111056
URL https://reader.elsevier.com/reader/sd/pii/S0927776520302861?token=8C7C51DD948F7F252316AFE7249CDE88B4962FA53DA397D3DA94EE29E126BAFEE7873C42AD50352EA4ED6A9F6C07710B
Languageen angielski
File
Major R. (i in.) - Patient specific implants...pdf 2.58 MB
Score (nominal)100
Score sourcejournalList
ScoreMinisterial score = 100.0, 22-09-2020, ArticleFromJournal
Publication indicators Scopus Citations = 0; WoS Citations = 0; Scopus SNIP (Source Normalised Impact per Paper): 2018 = 1.042; WoS Impact Factor: 2018 = 3.973 (2) - 2018=4.18 (5)
Citation count*1 (2020-09-23)
Additional fields
UwagiThis project is implemented under the Program for M-ERA.NET-2016/232/2017 Patient-specific bioactive, antimicrobial PLA-PGA/ti-tanium implants for large jawbone defects after tumour resection “jawIMPLANT”, funded by the National Centre for Research and Development.
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* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.
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