Fenton-type reaction grafting of polyvinylpyrrolidone onto polypropylene membrane for improving hemo- and biocompatibility
Authors:
- Ilona Łojszczyk,
- Aleksandra Kuźmińska,
- Beata Aleksandra Butruk-Raszeja,
- Tomasz Ciach
Abstract
Known techniques for modification of polypropylene membranes (PPm) often require modification of the membrane in its entire volume (i.e. at the manufacturing stage), which may affect its properties. In the present work, the authors proposed a simple method for PPm hydrophilization. The process involves a two-step Fenton-type reaction, with ethylene glycol dimethacrylate (EGDMA) as a crosslinking agent and cumene hydroperoxide (CHP) as a source of free radicals. This hydrogel coating aims to enhance membrane hemocompatible and biocompatible properties. The biggest advantage of the proposed technique is the change of materials' surface properties, without interfering with its internal structure. Microscopic (SEM) and spectroscopic (FTIR-ATR) analyses confirmed the presence of hydrogel coating on PPm surfaces. Additionally, the evaluation of the surface density of the coating showed that the thickness of the coating increases with the reaction time and CHP concentration. The applied coatings significantly increase surface hydrophilicity (contact angle for PPm: 128.58° ± 0.52°, for all modified surfaces <53.31° ± 2.03°). The cytotoxicity test (XTT assay) proved biocompatibility of the PVP coating – cell viability remained above 90% for all variants tested. The modification resulted in a decrease in fibrinogen adsorption (of at least about 16%) and in a number of surface-adhered platelets. The assay evaluating the amount of secreted cell adhesion molecules (ICAM-1) showed a significant reduction (of at least about 50%) in the expression of ICAM-1 for all hydrogel-modified surfaces.
- Record ID
- WUT5c0d41abfcb94801a481670efc7f7b10
- Author
- Journal series
- Materials Science & Engineering C - Materials for Biological Applications, ISSN 0928-4931, e-ISSN 1873-0191
- Issue year
- 2020
- Vol
- 113
- Pages
- 1-11
- Article number
- 110960
- Keywords in English
- polypropylene, membrane, hydrogel, surface modification
- ASJC Classification
- ; ; ;
- DOI
- DOI:10.1016/j.msec.2020.110960 Opening in a new tab
- URL
- https://reader.elsevier.com/reader/sd/pii/S0928493119337749?token=8F8A9DAA7A68E0B61839BE4498A7A9DFF26014B83CF9E8814DFC5EFD9D247CF94132AED5FED391359113D8E5CDF358BD Opening in a new tab
- Language
- (en) English
- License
- File
-
- File: 1
- Fenton-type reaction grafting of polyvinylpyrrolidone onto polypropylene membrane for improving hemo- and biocompatibility, File Łojszczyk I. (i in.) - Fenton-type reaction...pdf / 4 MB
- Łojszczyk I. (i in.) - Fenton-type reaction...pdf
- publication date: 11-05-2020
- Fenton-type reaction grafting of polyvinylpyrrolidone onto polypropylene membrane for improving hemo- and biocompatibility, File Łojszczyk I. (i in.) - Fenton-type reaction...pdf / 4 MB
-
- Score (nominal)
- 140
- Score source
- journalList
- Score
- = 140.0, 11-05-2022, ArticleFromJournal
- Publication indicators
- = 7; = 3; = 6; : 2017 = 1.384; : 2020 (2 years) = 7.328 - 2020 (5 years) =6.654
- Citation count
- 8
- Additional fields
- Uwagi: The presented work has been supported by the project: “Study on hemocompatibility of modified polymer surfaces” – Preludium 8 - financed by The National Science Centre (grant agreement no. UMO-2014/15/N/ST8/02717), Poland. The authors would like to thank PhD Michał Wojasiński from the Warsaw University of Technology for performing the tensile strength tests and PhD Jakub W. Trzciński for the help with the water permeability tests.
- Uniform Resource Identifier
- https://repo.pw.edu.pl/info/article/WUT5c0d41abfcb94801a481670efc7f7b10/
- URN
urn:pw-repo:WUT5c0d41abfcb94801a481670efc7f7b10
* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or PerishOpening in a new tab system.