New highly selective porphyrin-based nanophotosensitizer investigated using a microfluidic system

Katarzyna Tokarska , Elżbieta Jastrzębska , Michał Chudy , Arur Dybko , Urszula Bazylińska , Kazimiera Anna Wilk , Zbigniew Brzózka

Abstract

Herein we present a simply hybrid PDMS/glass microfluidic device for assessment of cyto- and photocytotoxicity of meso-tetraphenylporphyrin nanocapsules (TPP NCs). Layer by layer approach was used to synthesize the long-sustained release oil-core polyelectrolyte NCs with high encapsulation efficiency (EE > 90%). The proposed microsystem enables simultaneous mono-, coculture and mixed culture of A549 lung cancer and MRC-5 normal lung cells.

Author Katarzyna Tokarska (FC / CMB)
Katarzyna Tokarska,,
- Chair of Medical Biotechnology
, Elżbieta Jastrzębska (FC / CMB)
Elżbieta Jastrzębska,,
- Chair of Medical Biotechnology
, Michał Chudy (FC / CMB)
Michał Chudy,,
- Chair of Medical Biotechnology
, Arur Dybko - [Warsaw University of Technology (PW)]
Arur Dybko,,
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- Politechnika Warszawska
, Urszula Bazylińska - [Wrocław University of Science and Technology]
Urszula Bazylińska,,
-
-
, Kazimiera Anna Wilk - [Wrocław University of Science and Technology]
Kazimiera Anna Wilk,,
-
-
, Zbigniew Brzózka (FC / CMB)
Zbigniew Brzózka,,
- Chair of Medical Biotechnology
Journal series20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016
Issue year2016
Pages1091-1092
Languageen angielski
Score (nominal)0
Score sourcejournalList
ScoreMinisterial score = 0.0, 31-01-2020, ArticleFromJournal
Ministerial score (2013-2016) = 0.0, 31-01-2020, ArticleFromJournal
Publication indicators Scopus Citations = 1
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