Particles on the lung surface - physicochemical and hydrodynamic effects
Tomasz Robert Sosnowski
AbstractThe paper highlights and discusses the role of interfacial phenomena in the interactions between inhaled solid particles with different properties (size, structure, surface characteristics) and air/liquid interface of the alveolar region of the lungs. The greatest attention is paid to man-made nanosized and nanostructured particles which often belong to the class of “engineered particles”. Their applications in several novel technologies may be associated with accidental particle release to the air and formation of potentially harmful aerosol. Extraordinary, dynamic surface-active properties of the lung surfactant, which are responsible for several physiological functions - including the pulmonary mass transfer - may be altered by such inhaled particles in a material- and dose-dependent manner. Certain effects can be assessed by specialized experimental in vitro methods allowing predictions of possible in vivo interactions. On the other hand, interactions with the lung surfactant can modify the original properties of inhaled particles which in turn will influence their bioavailability or toxicity. All mentioned effects are dependent on particles properties as proven by numerous studies, however such results should be carefully judged due to essential differences in experimental methodology used. The paper also discusses some ideas related to the practical meaning of discussed effects for novel concepts of pulmonary drug delivery by inhalation.
|Journal series||Current Opinion in Colloid & Interface Science, ISSN 1359-0294|
|Publication size in sheets||0.5|
|Keywords in English||lung surfactant, surface tension, Marangoni effects, adsorption|
|Score|| = 40.0, 03-01-2018, ArticleFromJournal|
= 40.0, 03-01-2018, ArticleFromJournal
|Publication indicators||: 2016 = 6.136 (2) - 2016=6.831 (5)|
* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.