Optical Detection of Ketoprofen by Its Electropolymerization on an Indium Tin Oxide-Coated Optical Fiber Probe
Robert Bogdanowicz , Paweł Niedziałkowski , Michał Sobaszek , Dariusz Burnat , Wioleta Białobrzeska , Zofia Cebula , Petr Sezemsky , Marcin Koba , Vitezslav Stranak , Tadeusz Ossowski , Mateusz Jakub Śmietana
AbstractIn this work an application of optical fiber sensors for real-time optical monitoring of electrochemical deposition of ketoprofen during its anodic oxidation is discussed. The sensors were fabricated by reactive magnetron sputtering of indium tin oxide (ITO) on a 2.5 cm-long core of polymer-clad silica fibers. ITO tuned in optical properties and thickness allows for achieving a lossy-mode resonance (LMR) phenomenon and it can be simultaneously applied as an electrode in an electrochemical setup. The ITO-LMR electrode allows for optical monitoring of changes occurring at the electrode during electrochemical processing. The studies have shown that the ITO-LMR sensor’s spectral response strongly depends on electrochemical modification of its surface by ketoprofen. The effect can be applied for real-time detection of ketoprofen. The obtained sensitivities reached over 1400 nm/M (nm·mg−1·L) and 16,400 a.u./M (a.u.·mg−1·L) for resonance wavelength and transmission shifts, respectively. The proposed method is a valuable alternative for the analysis of ketoprofen within the concentration range of 0.25–250 μg mL−1, and allows for its determination at therapeutic and toxic levels. The proposed novel sensing approach provides a promising strategy for both optical and electrochemical detection of electrochemical modifications of ITO or its surface by various compounds.
|Journal series||Sensors [SENSORS-BASEL], ISSN 1424-8220, (A 30 pkt)|
|Publication size in sheets||0.7|
|Keywords in English||ketoprofen; anti-inflammatory drug; drug analysis; optical fiber sensor; reactive magnetron sputtering thin film; indium tin oxide (ITO); lossy-mode resonance (LMR); electrochemistry; electropolymerization|
|ASJC Classification||; ; ;|
|project||x. Project leader: Śmietana Mateusz Jakub,
, Phone: (22) 234 63 64, start date 20-05-2015, planned end date 19-05-2019, IMiO/2015/NCN/2, Implemented
|Score||= 30.0, 24-07-2019, ArticleFromJournal|
|Publication indicators||= 3; : 2016 = 1.393; : 2017 = 2.475 (2) - 2017=3.014 (5)|
|Citation count*||5 (2019-07-10)|
* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.