Optical Detection of Ketoprofen by Its Electropolymerization on an Indium Tin Oxide-Coated Optical Fiber Probe

Robert Bogdanowicz , Paweł Niedziałkowski , Michał Sobaszek , Dariusz Burnat , Wioleta Białobrzeska , Zofia Cebula , Petr Sezemsky , Marcin Koba , Vitezslav Stranak , Tadeusz Ossowski , Mateusz Jakub Śmietana

Abstract

In this work an application of optical fiber sensors for real-time optical monitoring of electrochemical deposition of ketoprofen during its anodic oxidation is discussed. The sensors were fabricated by reactive magnetron sputtering of indium tin oxide (ITO) on a 2.5 cm-long core of polymer-clad silica fibers. ITO tuned in optical properties and thickness allows for achieving a lossy-mode resonance (LMR) phenomenon and it can be simultaneously applied as an electrode in an electrochemical setup. The ITO-LMR electrode allows for optical monitoring of changes occurring at the electrode during electrochemical processing. The studies have shown that the ITO-LMR sensor’s spectral response strongly depends on electrochemical modification of its surface by ketoprofen. The effect can be applied for real-time detection of ketoprofen. The obtained sensitivities reached over 1400 nm/M (nm·mg−1·L) and 16,400 a.u./M (a.u.·mg−1·L) for resonance wavelength and transmission shifts, respectively. The proposed method is a valuable alternative for the analysis of ketoprofen within the concentration range of 0.25–250 μg mL−1, and allows for its determination at therapeutic and toxic levels. The proposed novel sensing approach provides a promising strategy for both optical and electrochemical detection of electrochemical modifications of ITO or its surface by various compounds.
Author Robert Bogdanowicz - Gdańsk University of Technology (PG)
Robert Bogdanowicz,,
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, Paweł Niedziałkowski
Paweł Niedziałkowski,,
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, Michał Sobaszek - Gdańsk University of Technology (PG)
Michał Sobaszek,,
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, Dariusz Burnat
Dariusz Burnat,,
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, Wioleta Białobrzeska
Wioleta Białobrzeska,,
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, Zofia Cebula
Zofia Cebula,,
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, Petr Sezemsky
Petr Sezemsky,,
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, Marcin Koba
Marcin Koba,,
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, Vitezslav Stranak
Vitezslav Stranak,,
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, Tadeusz Ossowski
Tadeusz Ossowski,,
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et al.`
Journal seriesSensors, ISSN 1424-8220, (A 30 pkt)
Issue year2018
Vol18
No5
Pages1-15
Publication size in sheets0.7
Keywords in Englishketoprofen; anti-inflammatory drug; drug analysis; optical fiber sensor; reactive magnetron sputtering thin film; indium tin oxide (ITO); lossy-mode resonance (LMR); electrochemistry; electropolymerization
DOIDOI:10.3390/s18051361
URL http://www.mdpi.com/1424-8220/18/5/1361
projectx. Project leader: Śmietana Mateusz Jakub, , Phone: (22) 234 63 64, start date 20-05-2015, planned end date 19-05-2019, IMiO/2015/NCN/2, Implemented
WEiTI Projects financed by NSC [Projekty finansowane przez NCN]
Languageen angielski
Score (nominal)30
ScoreMinisterial score = 30.0, 07-05-2018, ArticleFromJournal
Ministerial score (2013-2016) = 30.0, 07-05-2018, ArticleFromJournal
Publication indicators WoS Impact Factor: 2016 = 2.677 (2) - 2016=2.964 (5)
Citation count*1 (2018-12-10)
Additional fields
article number1361
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* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.
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