Optical Detection of Ketoprofen by Its Electropolymerization on an Indium Tin Oxide-Coated Optical Fiber Probe

Robert Bogdanowicz , Paweł Niedziałkowski , Michał Sobaszek , Dariusz Burnat , Wioleta Białobrzeska , Zofia Cebula , Petr Sezemsky , Marcin Koba , Vitezslav Stranak , Tadeusz Ossowski , Mateusz Jakub Śmietana


In this work an application of optical fiber sensors for real-time optical monitoring of electrochemical deposition of ketoprofen during its anodic oxidation is discussed. The sensors were fabricated by reactive magnetron sputtering of indium tin oxide (ITO) on a 2.5 cm-long core of polymer-clad silica fibers. ITO tuned in optical properties and thickness allows for achieving a lossy-mode resonance (LMR) phenomenon and it can be simultaneously applied as an electrode in an electrochemical setup. The ITO-LMR electrode allows for optical monitoring of changes occurring at the electrode during electrochemical processing. The studies have shown that the ITO-LMR sensor’s spectral response strongly depends on electrochemical modification of its surface by ketoprofen. The effect can be applied for real-time detection of ketoprofen. The obtained sensitivities reached over 1400 nm/M (nm·mg−1·L) and 16,400 a.u./M (a.u.·mg−1·L) for resonance wavelength and transmission shifts, respectively. The proposed method is a valuable alternative for the analysis of ketoprofen within the concentration range of 0.25–250 μg mL−1, and allows for its determination at therapeutic and toxic levels. The proposed novel sensing approach provides a promising strategy for both optical and electrochemical detection of electrochemical modifications of ITO or its surface by various compounds.
Author Robert Bogdanowicz - Gdańsk University of Technology (PG) [Gdańsk University of Technology (PG)]
Robert Bogdanowicz,,
- Politechnika Gdańska
, Paweł Niedziałkowski - [Uniwersytet Gdanski]
Paweł Niedziałkowski,,
, Michał Sobaszek - Gdańsk University of Technology (PG) [Gdańsk University of Technology (PG)]
Michał Sobaszek,,
- Politechnika Gdańska
, Dariusz Burnat (FEIT / MO)
Dariusz Burnat,,
- The Institute of Microelectronics and Optoelectronics
, Wioleta Białobrzeska - [Uniwersytet Gdanski]
Wioleta Białobrzeska,,
, Zofia Cebula - [Uniwersytet Gdanski]
Zofia Cebula,,
, Petr Sezemsky - [Jihoceská Univerzita v Ceských Budejovicích]
Petr Sezemsky,,
, Marcin Koba - [Warsaw University of Technology (PW), MNiSW [80]]
Marcin Koba,,
- Politechnika Warszawska
, Vitezslav Stranak - [Jihoceská Univerzita v Ceských Budejovicích]
Vitezslav Stranak,,
, Tadeusz Ossowski - [Uniwersytet Gdanski]
Tadeusz Ossowski,,
et al.`
Journal seriesSensors, [SENSORS-BASEL], ISSN 1424-8220, (A 30 pkt)
Issue year2018
Publication size in sheets0.7
Keywords in Englishketoprofen; anti-inflammatory drug; drug analysis; optical fiber sensor; reactive magnetron sputtering thin film; indium tin oxide (ITO); lossy-mode resonance (LMR); electrochemistry; electropolymerization
ASJC Classification2208 Electrical and Electronic Engineering; 1303 Biochemistry; 3107 Atomic and Molecular Physics, and Optics; 1602 Analytical Chemistry
URL http://www.mdpi.com/1424-8220/18/5/1361
Projectx. Project leader: Śmietana Mateusz Jakub, , Phone: (22) 234 63 64, start date 20-05-2015, planned end date 19-05-2019, IMiO/2015/NCN/2, Implemented
WEiTI Projects financed by NSC [Projekty finansowane przez NCN]
Languageen angielski
Score (nominal)30
Score sourcejournalList
ScoreMinisterial score = 30.0, 16-01-2020, ArticleFromJournal
Publication indicators WoS Citations = 4; Scopus Citations = 3; GS Citations = 7.0; Scopus SNIP (Source Normalised Impact per Paper): 2016 = 1.393; WoS Impact Factor: 2018 = 3.031 (2) - 2018=3.302 (5)
Citation count*7 (2020-01-04)
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article number1361
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* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.
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