The phase behavior in supercritical carbon dioxide of hyperbranched copolymers with architectural variations

Paweł Parzuchowski , Jacek Gregorowicz , Edyta Wawrzyńska , Dominik Wiącek , Gabriel Rokicki

Abstract

Hyperbranched polymers (HBPs) have been known and extensively investigated for over two decades. However, there are still areas that need to be explored. Recently, much effort has been placed in developing drug delivery systems based on macromolecules of three-dimensional structure. This paper describes the synthesis of hyperbranched copolyesters of 2,2-bis(hydroxymethyl)propionic acid (bis-MPA) containing small amounts (5 or 10%) of chain extending units of various lengths and their phase behavior in supercritical carbon dioxide (scCO2) after modification with trifluoroacetic anhydride. The structure of the copolyesters was confirmed with 1H and 13C NMR, FTIR spectroscopies and MALDI-TOF mass spectrometry. The phase behavior of the polymers in supercritical carbon dioxide was explored as a function of concentration and temperature. It was shown that polymers containing 5% (in respect to bis-MPA) of chain extending units of the moderate length (5-hydroxypentanoate or 6-hydroxyhexanoate) exhibited the lowest phase transition parameters in supercritical carbon dioxide. © 2015 Elsevier B.V.
Author Paweł Parzuchowski (FC / CPCT)
Paweł Parzuchowski,,
- Chair Of Polymer Chemistry And Technology
, Jacek Gregorowicz - Institute of Physical Chemistry Polish Academy of Sciences (IChF PAN) [Polska Akademia Nauk (PAN)] [Institute of Physical Chemistry of the Polish Academy of Sciences]
Jacek Gregorowicz,,
-
-
, Edyta Wawrzyńska (FC / CPCT)
Edyta Wawrzyńska,,
- Chair Of Polymer Chemistry And Technology
, Dominik Wiącek (FC / CPCT)
Dominik Wiącek,,
- Chair Of Polymer Chemistry And Technology
, Gabriel Rokicki (FC / CPCT)
Gabriel Rokicki,,
- Chair Of Polymer Chemistry And Technology
Journal seriesJournal of Supercritical Fluids, ISSN 0896-8446, (A 35 pkt)
Issue year2016
Vol107
Pages657-668
Publication size in sheets0.55
Keywords in EnglishHyperbranched polymer; Polyester; Phase behavior; Supercritical carbon dioxide
ASJC Classification1606 Physical and Theoretical Chemistry; 3104 Condensed Matter Physics; 1500 General Chemical Engineering
DOIDOI:10.1016/j.supflu.2015.07.028
URL http://www.sciencedirect.com/science/article/pii/S0896844615300814
Languageen angielski
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wdpb_publikacje_pliki_plik_publikacja_2640_org.pdf 1.54 MB
Score (nominal)35
ScoreMinisterial score = 35.0, 05-09-2019, ArticleFromJournal
Ministerial score (2013-2016) = 35.0, 05-09-2019, ArticleFromJournal
Publication indicators WoS Citations = 0; Scopus Citations = 0; Scopus SNIP (Source Normalised Impact per Paper): 2016 = 1.266; WoS Impact Factor: 2016 = 2.991 (2) - 2016=2.842 (5)
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