Poly(ɛ-caprolactone) and Its Biodegradation
- Joanna Idaszek,
- A. Bruinink,
- Wojciech Święszkowski
Poly(ε-caprolactone), PCL, is a biodegradable aliphatic polyester which exhibits very good bioacceptance, high blend miscibility and drug permeability. Furthermore, the excellent solubility in various solvents, thermal stability and rheological properties make PCL highly compatible with many scaffold fabrication techniques, including the extrusion-based systems belonging to the booming additive manufacturing. Those features, combined with regulatory approval and relatively low price, led to extensive studies of PCL as a biomaterial for tissue engineering applications and drug delivery systems. However, PCL undergoes relatively slow degradation and its mechanical properties are lower than those of the other medical polyesters. This limits the applicability of PCL to non-load bearing and slowly resorbable scaffolds.To overcome the aforementioned drawbacks and widen the application-spectrum, a variety of PCL-based biomaterials was synthesized and investigated. Those include copolymers, blends and homo- and co-polymer based bioactive composites. Recently, also ternary composites were developed and studied as biomaterials for bone tissue regeneration. All of the above listed biomaterials preserved the excellent processability of PCL but had altered mechanical properties and hydrolytic stability.This review aims to give an overview of the in vitro and in vivo degradation of PCL, including its mechanism, and the effect of the aforementioned modifications of PCL on degradation rate of the obtained biomaterials. The enhanced degradation profiles will be correlated with changes in the morphological and physicochemical properties of the materials, such as crystallinity, molecular weight and mass loss, giving an insight into possible hydrolysis mechanisms. Moreover, suitability of the biomaterials for bone tissue regeneration will be discussed by describing the impact of a given modification on the initial mechanical properties and their evolution during degradation.
- Record ID
- Publication size in sheets
- Henderson Bruce Bruce Henderson (eds.): Polycaprolactones: Properties, Applications and Selected Research, 2017, Nova Science Publishers, ISBN 978-1-53610-583-4
- (en) English
- Score (nominal)
- Score source
- = 5.0, 14-06-2021, MonographChapterAuthor
- Uniform Resource Identifier
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