Nanostructural haemocompatible coatings for the internal side of artificial blood vessels

K. Trembecka-Wojciga , Roman Major , J.M. Lackner , Beata Aleksandra Butruk-Raszeja , M. Sanak , Bogusław Major

Abstract

The main goal of the work was to elaborate low thrombogenicity of surface inside tube-like elements for cardiovascular system support by combination of low-temperature glow discharge and hydrogel coatings to inhibit blood-clotting cascade activation. A large share of amorphous phase silicon was observed in the microstructure analysis. The crystalline elements were uniformly distributed in the amorphous structure. Combination of low thickness, the proper microstructure and density of the coatings provided a highly flexible nature of the whole system. The blood-material interaction was analyzed in vitro in dynamic conditions by using a designed and fabricated novel blood flow simulator. Coatings deposited by the glow discharge expressed good hemocopatibile properties. The use of hydrogel coatings did not reduce coagulation parameter. Hydrogel coatings did not improve the hemocompatibility of the surface modified with carbon based coatings. Modification of surface with hydrogel resulted in further increased risk of hemolysis.
Author K. Trembecka-Wojciga
K. Trembecka-Wojciga,,
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, Roman Major - Instytut Metalurgii i Inżynierii Materiałowej PAN (IMIM)
Roman Major,,
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, J.M. Lackner
J.M. Lackner,,
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, Beata Aleksandra Butruk-Raszeja ZBIB
Beata Aleksandra Butruk-Raszeja,,
- Department of Biotechnology and Bioprocess Engineering
, M. Sanak
M. Sanak,,
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, Bogusław Major
Bogusław Major,,
-
Journal seriesIOP Conference Series: Materials Science and Engineering, ISSN 1757-8981, e-ISSN 1757-899X
Issue year2016
Vol119
Pages1-14
Publication size in sheets0.65
ConferenceInternational Conference on Materials Processing and Product Engineering (MPPE 2015), 03-11-2015 - 05-11-2015, Leoben, Austria
DOIDOI:10.1088/1757-899X/119/1/012030
URL http://iopscience.iop.org/article/10.1088/1757-899X/119/1/012030/pdf
Languageen angielski
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Trembecka-Wojciga K. (i in.) - Nanostructural haemocompatible coatings....pdf 1.29 MB
Score (nominal)5
ScoreMinisterial score = 0.0, 28-11-2017, ArticleFromJournal
Ministerial score (2013-2016) = 5.0, 28-11-2017, ArticleFromJournal - czasopismo zagraniczne spoza list
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