Assessment of taste masking of captopril by ion-exchange resins using electronic gustatory system
Authors:
- Mellisa T. R. Chikukwa,
- Małgorzata Łabańska,
- Aleksandra B. Korzeniowska,
- Patrycja Ciosek-Skibińska,
- Roderick B. Walker,
- Sandile M. M. Khamanga
Abstract
The objective of the study was to mask the unpleasant taste of captopril (CPT). Taste masking was achieved by complexation of CPT with a basic ion exchange resin, Dowex® 66, using the batch method. Dowex® 66 was used for the adsorption of CPT, and physical and chemical parameters of the CPT resinates complex were evaluated. A central composite design was used to generate the experiments for the manufacture of resinates using different process and formulation variables. In vitro dissolution studies were performed for 2 h in 0.01N HCl (pH 1.6) using USP Apparatus I. The compatibility of CPT and the resin was evaluated by Fourier transform infrared (FTIR), differential scanning calorimetry (DSC), and powder X-ray diffraction (PXRD). The resinates were evaluated for micromeritic properties and further characterised using FTIR, DSC, and PXRD. Response surface methodology was used to determine the significance of input variables on the CPT content and release. The CPT resin ratio was found to have a significant impact on content of the resinates and on CPT release. The formulations were also studied for taste masking ability by means of an electronic gustatory system – electronic tongue.
- Record ID
- WUT4ae2371db8974980abd53d57d7e8d124
- Author
- Journal series
- Pharmaceutical Development and Technology, ISSN 1083-7450, e-ISSN 1097-9867
- Issue year
- 2020
- Vol
- 25
- Pages
- 281-289
- Publication size in sheets
- 0.50
- Keywords in English
- captopril, ion exchange resin, resinate, electronic tongue, taste-masking, sensor array
- ASJC Classification
- ;
- DOI
- DOI:10.1080/10837450.2019.1687520 Opening in a new tab
- URL
- https://www.tandfonline.com/doi/full/10.1080/10837450.2019.1687520?scroll=top&needAccess=true Opening in a new tab
- Language
- (en) English
- File
-
- File: 1
- wdpb_publikacje_pliki_plik_publikacja_3882_org-1.pdf
-
- Score (nominal)
- 40
- Score source
- journalList
- Score
- = 40.0, 09-05-2022, ArticleFromJournal
- Publication indicators
- = 6; = 1; : 2016 = 0.705; : 2020 (2 years) = 3.133 - 2020 (5 years) =2.857
- Uniform Resource Identifier
- https://repo.pw.edu.pl/info/article/WUT4ae2371db8974980abd53d57d7e8d124/
- URN
urn:pw-repo:WUT4ae2371db8974980abd53d57d7e8d124
* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or PerishOpening in a new tab system.