Bone regeneration potential of the new chitosan-based alloplastic biomaterial

Witold Bojar , Martyna Kucharska , Tomasz Ciach , Koperski Łukasz , Zenon Jastrzębski , Michał Szałwiński


Over the last few years, alloplastic bone substitute materials are raising much interest as an alternative to autologic transplants and xenogenic materials especially in oral surgery. These non-immunogenic and completely resorbable biomaterials are becoming the basis for complete and predictable guided bone regeneration in many cases. The objective of our research was to evaluate the dynamics of bone formation in rats’ skulls after implantation of the new chitosan/tricalcium phosphate/alginate biomaterial in comparison to the commercially available alloplastic bone graft. A total of 45 adult male rats weighing 300–400 g were used for the study. The 85-mm-diameter defects in calvaria bone were prepared with a trephine bur, and then filled with the bone substitute materials: chitosan/tricalcium phosphate/alginate or easy-graft Classic (Degradable Solutions AG) (EA) or left just with the blood clot. Animals were sacrificed at 1 and 3 months for histological, histomorphometrical and micro-tomographic evaluations. Histological evaluation at 1 month showed early new bone formation, observed around the experimental biomaterial (CH/TCP/Alg). There were no features of purulent inflammation and necrosis or granulomatous inflammation. Microscopic examination after 3 months following the surgery revealed trabecular bone formation around chitosan-based bone graft with no significant inflammatory response. Less satisfactory and differing results were observed for the commercially available EA and control blood clot. The tested material (chitosan) showed a high degree of biocompatibility and osteoconductivity in comparison with the control groups.
Author Witold Bojar - [National Medicines Institute, Warsaw]
Witold Bojar,,
, Martyna Kucharska (FCPE)
Martyna Kucharska,,
- Faculty of Chemical and Process Engineering
, Tomasz Ciach (FCPE / DBBE)
Tomasz Ciach,,
- Department of Biotechnology and Bioprocess Engineering
, Koperski Łukasz
Koperski Łukasz,,
, Zenon Jastrzębski - [National Medicines Institute]
Zenon Jastrzębski,,
, Michał Szałwiński - [Medical University of Warsaw]
Michał Szałwiński,,
Journal seriesJournal of Biomaterials Applications, ISSN 0885-3282, (A 30 pkt)
Issue year2014
Publication size in sheets0.5
Keywords in Englishalginate, bone substitute material, chitosan, guided bone regeneration, β-tricalcium phosphate, rat model
ASJC Classification2204 Biomedical Engineering; 2502 Biomaterials
Languageen angielski
Bojar W. (i in.) - Bone regeneration potential....pdf 820.02 KB
Score (nominal)30
ScoreMinisterial score = 30.0, 05-09-2019, ArticleFromJournal
Ministerial score (2013-2016) = 30.0, 05-09-2019, ArticleFromJournal
Publication indicators Scopus Citations = 20; WoS Citations = 18; Scopus SNIP (Source Normalised Impact per Paper): 2014 = 1.011; WoS Impact Factor: 2014 = 2.197 (2) - 2014=2.559 (5)
Citation count*26 (2020-01-13)
Share Share

Get link to the record

* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.
Are you sure?