Bone regeneration potential of the new chitosan-based alloplastic biomaterial
Witold Bojar , Martyna Kucharska , Tomasz Ciach , Koperski Łukasz , Zenon Jastrzębski , Michał Szałwiński
AbstractOver the last few years, alloplastic bone substitute materials are raising much interest as an alternative to autologic transplants and xenogenic materials especially in oral surgery. These non-immunogenic and completely resorbable biomaterials are becoming the basis for complete and predictable guided bone regeneration in many cases. The objective of our research was to evaluate the dynamics of bone formation in rats’ skulls after implantation of the new chitosan/tricalcium phosphate/alginate biomaterial in comparison to the commercially available alloplastic bone graft. A total of 45 adult male rats weighing 300–400 g were used for the study. The 85-mm-diameter defects in calvaria bone were prepared with a trephine bur, and then filled with the bone substitute materials: chitosan/tricalcium phosphate/alginate or easy-graft Classic (Degradable Solutions AG) (EA) or left just with the blood clot. Animals were sacrificed at 1 and 3 months for histological, histomorphometrical and micro-tomographic evaluations. Histological evaluation at 1 month showed early new bone formation, observed around the experimental biomaterial (CH/TCP/Alg). There were no features of purulent inflammation and necrosis or granulomatous inflammation. Microscopic examination after 3 months following the surgery revealed trabecular bone formation around chitosan-based bone graft with no significant inflammatory response. Less satisfactory and differing results were observed for the commercially available EA and control blood clot. The tested material (chitosan) showed a high degree of biocompatibility and osteoconductivity in comparison with the control groups.
|Journal series||Journal of Biomaterials Applications, ISSN 0885-3282, (A 30 pkt)|
|Publication size in sheets||0.5|
|Keywords in English||alginate, bone substitute material, chitosan, guided bone regeneration, β-tricalcium phosphate, rat model|
|Score|| = 30.0, 05-09-2019, ArticleFromJournal|
= 30.0, 05-09-2019, ArticleFromJournal
|Publication indicators||= 20; = 18; : 2014 = 1.011; : 2014 = 2.197 (2) - 2014=2.559 (5)|
|Citation count*||26 (2020-01-13)|
* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.