3D-printed biological cell phantom for testing 3D quantitative phase imaging systems

Michał Ziemczonok , Arkadiusz Kuś , Piotr Wasylczyk , Małgorzata Kujawińska

Abstract

As the 3D quantitative phase imaging (QPI) methods mature, their further development calls for reliable tools and methods to characterize and compare their metrological parameters. We use refractive index engineering during two-photon laser photolithography to fabricate a life-scale phantom of a biological cell with internal structures that mimic optical and structural properties of mammalian cells. After verification with a number of reference techniques, the phantom is used to characterize the performance of a limited-angle holographic tomography microscope.
Author Michał Ziemczonok (FM / IMPh)
Michał Ziemczonok,,
- The Institute of Micromechanics and Photonics
, Arkadiusz Kuś (FM / IMPh)
Arkadiusz Kuś,,
- The Institute of Micromechanics and Photonics
, Piotr Wasylczyk - Photonic Nanostructure Facility (PNaF) [Faculty of Physics]
Piotr Wasylczyk,,
-
, Małgorzata Kujawińska (FM / IMPh)
Małgorzata Kujawińska,,
- The Institute of Micromechanics and Photonics
Journal seriesScientific Reports, ISSN 2045-2322, (N/A 140 pkt)
Issue year2019
Vol9
Pages1-9
Publication size in sheets0.5
Article number18872
Keywords in Englishlithography, phase-contrast microscopy
ASJC Classification1000 Multidisciplinary
DOIDOI:10.1038/s41598-019-55330-4
URL https://www.nature.com/articles/s41598-019-55330-4
ProjectTEAM TECH BiOpTo: Tomographic phase microscope for biomedical applications. Project leader: Kujawińska Małgorzata, , Phone: +48 22234-8489, start date 01-10-2016, planned end date 31-10-2019, 503/00093, Implemented
WM Program Operacyjny Inteligentny Rozwój (PO IR)
Languageen angielski
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Ziemczonok et al. - 2019 - 3D-printed biological cell phantom for testing 3D quantitative phase imaging systems.pdf 2.24 MB
Score (nominal)140
Score sourcejournalList
ScoreMinisterial score = 140.0, 01-02-2020, ArticleFromJournal
Publication indicators WoS Citations = 0; Scopus SNIP (Source Normalised Impact per Paper): 2016 = 1.401; WoS Impact Factor: 2018 = 4.011 (2) - 2018=4.525 (5)
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