Effect of clay nanoparticles on model lung surfactant: a potential marker of hazard from nanoaerosol inhalation

Dorota Kondej , Tomasz Robert Sosnowski

Abstract

This work investigates influence of different aluminosillicate nanoparticles (NPs) which are found in air in selected workplaces on the properties of the phospholipid (DPPC) monolayer at air–saline interface considered as ex vivo model of the lung surfactant (LS). The measurements were done under physiological-like conditions (deformable liquid interface at 37 °C) for NP concentrations matching the calculated lung doses after exposure in the working environment. Measured surface pressure–area (π–A) isotherms and compressibility curves demonstrated NP-induced changes in the structure and mechanical properties of the lipid monolayer. It was shown that hydrophilic nanomaterials (halloysite and bentonite) induced concentration-dependent impairment of DPPC’s ability of attaining high surface pressures on interfacial compression, suggesting a possibility of reduction of physiological function of natural LS. Hydrophobic montmorillonites affected DPPC monolayer in the opposite way; however, they significantly changed the mechanical properties of the air–liquid interface during compression. The results support the hypothesis of possible reduction or even degradation of the natural function of the lung surfactant induced by particle–phospholipid interactions after inhalation of nanoclays. Presented data do not only supplement the earlier results obtained with another LS model (animal-derived surfactant in oscillating bubble experiments) but also offer an explanation of physicochemical mechanisms responsible for detrimental effects which arise after deposition of inhaled nanomaterials on the surface of the respiratory system.
Author Dorota Kondej - [Central Institute for Labour Protection - National Research Institute (CIOP PIB)]
Dorota Kondej,,
-
- Centralny Instytut Ochrony Pracy-Państwowy Instytut Badawczy
, Tomasz Robert Sosnowski KIPZ
Tomasz Robert Sosnowski,,
- Chair of Integrated Process Engineering
Journal seriesEnvironmental Science and Pollution Research, ISSN 0944-1344
Issue year2016
Vol23
No5
Pages4660-4669
Publication size in sheets0.5
Keywords in Englishdust, nanotechnology, inhalation, pulmonary effects, surfactant
DOIDOI:10.1007/s11356-015-5610-4
URL http://link.springer.com/article/10.1007%2Fs11356-015-5610-4
Languageen angielski
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Kondej D., Sosnowski T. - Effect of clay....pdf 1,021.58 KB
Score (nominal)30
ScoreMinisterial score [Punktacja MNiSW] = 30.0, 28-11-2017, ArticleFromJournal
Ministerial score (2013-2016) [Punktacja MNiSW (2013-2016)] = 30.0, 28-11-2017, ArticleFromJournal
Publication indicators WoS Impact Factor [Impact Factor WoS]: 2016 = 2.741 (2) - 2016=3.023 (5)
Citation count*13 (2018-06-18)
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* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.
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