An evaluation of a mass transfer rate at the boundary of different release mechanisms in complex liquid dispersion

Agnieszka Markowska-Radomska , Ewa Dłuska

Abstract

The paper focuses on the development of the criteria for modelling mass transfer during release process at the boundary of diffusion and fragmentation in complex liquid dispersion, such as double emulsions. The proposed model for predicting release rates accounts for the effect of mass transfer resistance coupled with the emulsion structure and external release environment. The criteria of the applicability of the proposed model were formulated after verification by studies of drug release from O1/W/O2 emulsions, prepared in a Taylor–Couette flow bioreactor. It has been found that one or more mechanisms may dominate at different release stages, depending on the mixing intensity of the release medium and internal structure of double emulsions. The experimental analysis of release rates and the changes in the emulsion structure during the release process, revealed the existence of three mechanisms: (i) diffusion, (ii) diffusion and fragmentation—loss of the original structure from double emulsions to single emulsions and (iii) fragmentation. The criteria covering the diffusion release model have been formulated, as the shear rate ranges at the boundary of different mechanisms, and correspond to the values of the critical capillary numbers, which seemed to depend on the volume fraction of internal droplets of multiple emulsions.
Author Agnieszka Markowska-Radomska ZKTP
Agnieszka Markowska-Radomska,,
- Department of Process Kinetics and Thermodynamics
, Ewa Dłuska ZKTP
Ewa Dłuska,,
- Department of Process Kinetics and Thermodynamics
Journal seriesChemical Engineering and Processing, ISSN 0255-2701
Issue year2016
Vol101
Pages56-71
Publication size in sheets0.75
Keywords in Englishmass transfer mode, liquid dispersion, emulsion delivery system, diffusional release, fragmentation
DOIDOI:10.1016/j.cep.2015.12.006
URL http://www.sciencedirect.com/science/article/pii/S0255270115301562
Languageen angielski
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Score (nominal)30
ScoreMinisterial score = 30.0, 28-11-2017, ArticleFromJournal
Ministerial score (2013-2016) = 30.0, 28-11-2017, ArticleFromJournal
Publication indicators WoS Impact Factor: 2016 = 2.234 (2) - 2016=2.579 (5)
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* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.
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