Engineering of 2D Ti3C2 MXene surface charge and its influence on biological properties

Anita Rozmysłowska-Wojciechowska , Joanna Mitrzak , Aleksandra Szuplewska , Michał Chudy , Jarosław Woźniak , Mateusz Petrus , Tomasz Wojciechowski , Alexey S. Vasilchenko , Agnieszka Jastrzębska

Abstract

Current trends in the field of MXenes emphasize the importance of controlling their surface features for successful application in biotechnological areas. The ability to stabilize the surface properties of MXenes has been demonstrated here through surface charge engineering. It was thus determined how changing the surface charges of two-dimensional (2D) Ti3C2 MXene phase flakes using cationic polymeric poly-L-lysine (PLL) molecules affects the colloidal and biological properties of the resulting hybrid 2D nanomaterial. Electrostatic adsorption of PLL on the surface of delaminated 2D Ti3C2 flakes occurs efficiently, leads to changing an MXene's negative surface charge toward a positive value, which can also be effectively managed through pH changes. Analysis of bioactive properties revealed additional antibacterial functionality of the developed 2D Ti3C2/PLL MXene flakes concerning Escherichia. coli Gram-negative bacteria cells. A reduction of two orders of magnitude of viable cells was achieved at a concentration of 200 mg L-1. The in vitro analysis also showed lowered toxicity in the concentration range up to 375 mg L-1. The presented study demonstrates a feasible approach to control surface properties of 2D Ti3C2 MXene flakes through surface charge engineering which was also verified in vitro for usage in biotechnology or nanomedicine applications.

Author Anita Rozmysłowska-Wojciechowska (FMSE / DSMP)
Anita Rozmysłowska-Wojciechowska,,
- Division of Ceramic Materials and Polymers
, Joanna Mitrzak (WUT)
Joanna Mitrzak,,
- Warsaw University of Technology
, Aleksandra Szuplewska (FC / CMB)
Aleksandra Szuplewska,,
- Chair of Medical Biotechnology
, Michał Chudy (FC / CMB)
Michał Chudy,,
- Chair of Medical Biotechnology
, Jarosław Woźniak (FMSE / DSMP)
Jarosław Woźniak,,
- Division of Ceramic Materials and Polymers
, Mateusz Petrus (FMSE / DSMP)
Mateusz Petrus,,
- Division of Ceramic Materials and Polymers
, Tomasz Wojciechowski (FC / DCOC)
Tomasz Wojciechowski,,
- Department Of Catalysis And Organometallic Chemistry
, Alexey S. Vasilchenko - [Tyumen State University]
Alexey S. Vasilchenko,,
-
-
, Agnieszka Jastrzębska (FMSE / DSMP)
Agnieszka Jastrzębska,,
- Division of Ceramic Materials and Polymers
Journal seriesMaterials, ISSN 1996-1944
Issue year2020
Vol13
Pages1-18
Publication size in sheets0.85
Keywords in EnglishMXenes; delaminated Ti3C2; poly-L-lysine; antibacterial properties; cytotoxicity in vitro; mammalian cells
ASJC Classification2500 General Materials Science
DOIDOI:10.3390/ma13102347
URL https://www.mdpi.com/1996-1944/13/10/2347
Languageen angielski
File
materials-13-02347-v2.pdf 3.19 MB
Score (nominal)140
Score sourcejournalList
ScoreMinisterial score = 140.0, 24-09-2020, ArticleFromJournal
Publication indicators Scopus Citations = 0; Scopus SNIP (Source Normalised Impact per Paper): 2017 = 1.285; WoS Impact Factor: 2018 = 2.972 (2) - 2018=3.532 (5)
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