Regeneration of titanium oxide nano-coated long-period grating biosensor

Magdalena Dominik , Joanna Niedziółka-Jönsson , E. Roźniecka , Łukasz Wachnicki , Marek Godlewski , Predrag Mikulic , Wojtek J. Bock , Mateusz Jakub Śmietana


This work presents an application of sodium hydroxide (NaOH) as an effective method for regeneration of titanium oxide (TiO x ) nano-coated long-period grating (LPG) biosensor. Below 100 nm in thickness TiO x coating was deposited with atomic layer deposition (ALD) method on LPGs for enhancing their refractive index sensitivity up to 2912 nm/RIU in RI range 1.33-1.36 RIU. Next, the sensors were biofunctionalized in order to immobilize receptor (biotin) on their surface and used for selective avidin detection. After successful biofunctionalization process and avidin detection the sensors were washed in NaOH and biofunctionalized again. The proposed method for recovering the sensor does not cause decrease in its functional properties. As a result of the applied procedure the biosensor was fully regenerated.
Author Magdalena Dominik IMiO
Magdalena Dominik,,
- The Institute of Microelectronics and Optoelectronics
, Joanna Niedziółka-Jönsson
Joanna Niedziółka-Jönsson,,
, E. Roźniecka
E. Roźniecka,,
, Łukasz Wachnicki
Łukasz Wachnicki,,
, Marek Godlewski
Marek Godlewski,,
, Predrag Mikulic
Predrag Mikulic,,
, Wojtek J. Bock
Wojtek J. Bock,,
, Mateusz Jakub Śmietana IMiO
Mateusz Jakub Śmietana,,
- The Institute of Microelectronics and Optoelectronics
Publication size in sheets0.5
Book Lewis Elfed (eds.): Proceedings of the SPIE Sixth European Workshop on Optical Fibre Sensors, vol. 9916, 2016, SPIE, ISBN 9781510602199, 200 p., DOI:10.1117/12.2242681
Keywords in Englishthin films, titanium oxide, atomic layer deposition, long-period grating, refractive index sensing, biofunctionalization, biosensor regeneration
projectx. Project leader: Śmietana Mateusz Jakub, , Phone: (22) 234 63 64, start date 20-05-2015, planned end date 19-05-2019, IMiO/2015/NCN/2, Implemented
WEiTI Projects financed by NSC [Projekty finansowane przez NCN]
Languageen angielski
Score (nominal)15
ScoreMinisterial score [Punktacja MNiSW] = 15.0, 27-03-2017, BookChapterMatConf
Ministerial score (2013-2016) [Punktacja MNiSW (2013-2016)] = 15.0, 27-03-2017, BookChapterMatConf
Citation count*2 (2018-06-18)
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* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.