Regeneration of titanium oxide nano-coated long-period grating biosensor

Magdalena Dominik , Joanna Niedziółka-Jönsson , E. Roźniecka , Łukasz Wachnicki , Marek Godlewski , Predrag Mikulic , Wojtek J. Bock , Mateusz Jakub Śmietana


This work presents an application of sodium hydroxide (NaOH) as an effective method for regeneration of titanium oxide (TiO x ) nano-coated long-period grating (LPG) biosensor. Below 100 nm in thickness TiO x coating was deposited with atomic layer deposition (ALD) method on LPGs for enhancing their refractive index sensitivity up to 2912 nm/RIU in RI range 1.33-1.36 RIU. Next, the sensors were biofunctionalized in order to immobilize receptor (biotin) on their surface and used for selective avidin detection. After successful biofunctionalization process and avidin detection the sensors were washed in NaOH and biofunctionalized again. The proposed method for recovering the sensor does not cause decrease in its functional properties. As a result of the applied procedure the biosensor was fully regenerated.
Author Magdalena Dominik (FEIT / MO)
Magdalena Dominik,,
- The Institute of Microelectronics and Optoelectronics
, Joanna Niedziółka-Jönsson - [Institute of Physical Chemistry of the Polish Academy of Sciences]
Joanna Niedziółka-Jönsson,,
, E. Roźniecka - [Institute of Physical Chemistry of the Polish Academy of Sciences]
E. Roźniecka,,
, Łukasz Wachnicki - [Polish Academy of Sciences]
Łukasz Wachnicki,,
, Marek Godlewski - [Polish Academy of Sciences]
Marek Godlewski,,
, Predrag Mikulic - [Universite du Quebec en Outaouais]
Predrag Mikulic,,
, Wojtek J. Bock - [Universite du Quebec en Outaouais]
Wojtek J. Bock,,
, Mateusz Jakub Śmietana (FEIT / MO)
Mateusz Jakub Śmietana,,
- The Institute of Microelectronics and Optoelectronics
Publication size in sheets0.5
Book Lewis Elfed (eds.): Proceedings of the SPIE Sixth European Workshop on Optical Fibre Sensors, vol. 9916, 2016, PO Box 10 Bellingham WA 98227-0010 USA, SPIE, ISBN 9781510602199, 200 p., DOI:10.1117/12.2242681
991601.pdf / 421.61 KB / No licence information
Keywords in Englishthin films, titanium oxide, atomic layer deposition, long-period grating, refractive index sensing, biofunctionalization, biosensor regeneration
Projectx. Project leader: Śmietana Mateusz Jakub, , Phone: (22) 234 63 64, start date 20-05-2015, planned end date 19-05-2019, IMiO/2015/NCN/2, Implemented
WEiTI Projects financed by NSC [Projekty finansowane przez NCN]
Languageen angielski
Score (nominal)15
Score sourceconferenceIndex
ScoreMinisterial score = 15.0, 11-02-2020, BookChapterMatConfByConferenceseries
Ministerial score (2013-2016) = 15.0, 11-02-2020, BookChapterMatConfByConferenceseries
Publication indicators Scopus Citations = 2; WoS Citations = 3; GS Citations = 1.0
Citation count*1 (2020-08-18)
Share Share

Get link to the record

* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.
Are you sure?